香连丸对活动期溃疡性结肠炎患者自然杀伤T细胞功能的调节作用

Effect of Xianglian Pills on the Natural Killer Cells for Patients with Active Ulcerative Colitis

目的:探讨香连丸对活动期溃疡性结肠炎(UC)患者自然杀伤T细胞(NKT)功能的调节作用。方法:收集坚持随访行电子结肠镜的56例活动期UC患者,随机分为观察组与对照组各28例,分别使用香连丸及柳氮磺吡啶治疗,比较治疗前后外周血及肠黏膜内NKT及其胞内细胞因子γ干扰素(IFN-γ)和肿瘤坏死因子α(TNF-α)的百分含量。结果:治疗前两组患者NKT、IFN-γ及TNF-α均无统计学差异;治疗后两组患者临床表现均好转,且上述三项指标均呈不同程度回升,但上升幅度以观察组明显,且治疗后观察组上述三项指标均明显高于对照组(P<0.05)。结论:NKT降低是活动期UC的一个重要特征,香连丸可有效上调NKT、IFN-γ及TNF-α的含量,可能是香连丸治疗活动期UC的免疫机制之一。

Objective：To investigate the effect of Xianglian pills on the natural killer cells for patients with active ulcerative colitis.Methods：Collect adhere to follow-up line electronic colonoscopy in active 56 cases of patients with UC were randomly divided into observation group and the control group（n=28）,and Xianglian pills respectively using sulfonyl pyridine nitrogen treatment,compared before and after treatment within the peripheral blood and bowel mucosa of NKT and intracellular cytokine gamma interferon（IFN-gamma） and tumor necrosis factor alpha（TNF alpha） percentage.Results：Two groups of patients before treatment of NKT,IFN-gamma and TNF alpha had no statistical difference;Two groups of patients with clinical manifestations were improved after treatment,and the above three indicators are in varying degrees,but rise to observation group obviously,the above three indicators and observation after treatment group were significantly higher than control group（P0.05）.Conclusion：NKT reduce activity is an important characteristic of UC,can be effectively recovered Xianglian pills of NKT,IFN-gamma and the content of TNF alpha Xianglian pills may be one of the immune mechanism in active treatment of UC.