HIV/AIDS中医证型与T淋巴细胞亚群关系的研究

Research of relationship between HIV/AIDS syndrome differentiation type of TCM and T lymphocyte subsets

目的:探索HIV/AIDS中医证型与T细胞亚群的关系。方法:选择HIV/AIDS患者276例,健康对照者11名,均进行外周血T淋巴细胞亚群检测并对HIV/AIDS进行中医辨证分型。结果:HIV/AIDS各证型与健康人相比,在CD4/CD45RA、CD4/CD45RO、CD4/CD28、CD4/CD95多表现为显著性下降,CD8/CD38、CD8/CD95明显升高(P<0.05);各证型间比较,痰湿内蕴组与其它证型在CD4/CD45RO、CD4/CD28、CD8/CD38、CD8/CD95方面差异较显著(P<0.05),阴虚火旺证在CD4/CD45RO、CD8/CD25方面与气血亏虚证、脾肾两虚证差异较明显(P<0.05),而气血亏虚证、气血亏虚兼血瘀证、脾肾两虚证各免疫指标间差异较小,大多无统计学意义。结论:在HIV感染所致的免疫损害中,反映机体免疫功能改变的T淋巴细胞亚群与HIV/AIDS中医证型有一定关系,可为进一步研究HIV/AIDS中医证型及病机演变规律提供参考。

Objective： To explore the relationship between HIV/AIDS TCM syndrome differentiation type syndrome （TCM-SDT） and T-cell subsets. Methods： 276 cases of HIV/AIDS patients, 11 cases of healthy controls, were detected peripheral blood T lymphocyte subsets and HIV/AIDS TCM-SDT. Results： Compared to healthy people, HIV/AIDS patients significantly decreased in CD4/CD45RA, CD4/CD45RO. CD4/CD28, CD4/CD95, significantly higher in CD8/CD38, CD8/CD95 （P〈0.05）; comparison among different TCM-SDTs, phlegm-dampness accumulation syndrome was significant different in CD4/CD45RO, CD4/CD28, CD8/CD38, CD8/CD95 （P〈0.05）, yin deficiency and fire exuberance syndrome was significant different in CD4/ CD45RO, CD8/CD25 compared to qi-biood deficiency syndrome and asthenia of both the spleen and kidney syndrome （P〈0.05）; qi-blood deficiency syndrome, qi-biood deficiency and blood stasis syndrome and asthenia of both the spleen and kidney syndrome had no significant difference. Conclusion： HIV/AIDS TCM-SDT is related with T-cell subsets, this can be reference for further pathogenesis and syndrome differentiation study of TCM.