红景天苷对非酒精性脂肪性肝炎的降脂保肝作用研究

Jiangzhi and Hepatoprotective effect of salidroside on nonalcoholic fatty liver disease

目的:探讨中药红景天的主要成分红景天苷对高脂饮食诱导的金黄地鼠非酒精性脂肪性肝炎(NASH)的干预作用。方法:18只雄性金黄地鼠随机分成正常组、模型组和红景天苷组,除正常组外,其余两组均给予高脂饮食喂养6周以复制NASH模型;造模第3周起,红景天苷组给予红景天苷药液灌胃4周。6周后处死地鼠,收集标本,检测肝组织甘油三酯(TG)含量,血清天门冬氨酸氨基转移酶(AST)活性,对肝组织进行HE染色。结果:红景天苷能明显降低肝组织TG含量及血清AST活性,改善肝组织脂肪变性的病理状态。结论:红景天苷具有显著的抗NASH病理损伤的药理效应。

Objective： To explore the intervening effect of the main components of the rhodiola on the nonalcoholic fatty liver disease （NAFLD） for male golden hamsters induced by high-fat diets. Methods： Total 18 male golden hamsters were divided into control group, model group and salidroside group randomly. Male golden hamsters in the model group and salidroside group were fed with high fat diet for 6 weeks to reproduce NAFLD model. After the second week of feeding, male golden hamsters in the salidroside group were given a gavage of salidroside. All male golden hamsters were put to death at the 6 weeks and samples were collected. Hepatic tissue TG contents were detected. Serum AST activities were determined. Hepatic tissues were detected by HE staining. Results： Salidroside decreased hepatic tissue TG contents, serum AST activities and reduced the fatty degeneration in hepatocytes significantly. Conclusion： Salidroside has conspicuous pharmacological effect on the nonalcoholic fatty liver disease in male golden hamsters.