细胞因子疗法在肿瘤治疗中的应用

Cytokines therapy in tumor treatment

细胞因子在肿瘤的发生发展中起着重要作用，部分细胞因子的抗肿瘤机制研究较明确。目前应用于肿瘤临床治疗的细胞因子主要有干扰素（IFN）、白细胞介素（IL）、肿瘤坏死因子（TNF）。由于细胞因子疗法作用缺乏靶向性，不良反应多导致部分患者难以耐受，细胞因子疗法临床进展受限。提高疗效稳定性、减少不良反应仍是发展肿瘤细胞因子疗法的重中之重。

Cytokines play an important role in the genesis and development of tumor. Antitumor mech- anisms of some eytokines are clearly testified. Currently, the main cytokines used in tumor clinical treatments are interferons, interleukins and tumor necrosis factors. For the lack of specificity, there are too many side effects for some patients to continue. So the application range of cytokines in tumor clinical treatment is limited. The most important measures to develop cytokines therapy are improving the stability of curative effect and reducing side effects.