血清KL-6在肺癌放射性肺炎中的研究进展

Serum KL-6 in radioactive pneumonia with lung cancer

血清KL-6是由上皮性黏蛋白1（MUCl）基因编码的一类糖蛋白，是较早被公认的间质性肺疾病的特异性标志物，而且KL--6亦高表达于部分恶性肿瘤患者。近年的研究发现，血清KL-6与放射性肺炎的发生相关，监测血清KL-6可预测放射性肺炎的发生并评估疾病的严重程度及预后。

Serum KL-6 is a category of glycoprotein coded by the epithelium of sticky protein 1 （MUCI） gene, which has already been regarded as an indicator of interstitial lung diseases, and later found highly expressed in part of malignant tumor patients. In recent years, studies has found that serum KL-6 is associated with the incidence of radioactive pneumonia, and monitoring serum KL-6 can predict the occurrence of radioactive pneumonia as well assess the severity and prognosis of disease.