心复康口服液对心肌梗死后心力衰竭大鼠心脏功能的影响

Effect of Xinfukang oral liquid on cardiac function in heart failure rats after myocardial infarction

目的观察心复康口服液对心肌梗死后心力衰竭大鼠心脏功能的影响。方法 SD大鼠随机分为造模组90只与假手术组10只,造模组采用结扎左冠状动脉前降支致心肌梗死后心力衰竭大鼠模型,术后随机分为模型组、曲美他嗪组、心复康大剂量组、心复康小剂量组,每组大鼠不小于10只,各组连续灌胃给药8周,8周后行超声心动检测,观察大鼠心脏功能变化。结果与假手术比较,模型组LVIDd、LVIDs、LVEDV、LVESV显著升高(P<0.01),EF、FS、CO显著降低(P<0.01)。与模型组比较,曲美他嗪组、心复康口服液大剂量组、心复康口服液小剂量组LVIDd、LVIDs、LVEDV、LVESV显著降低(P<0.05或P<0.01),EF、FS、CO显著升高(P<0.01)。结论心复康口服液可改善心肌梗死后心力衰竭模型大鼠心脏功能。

Objective To study the effect of Xinfukangoral liquid （XFK） on cardiac function in heart failure rats after myocardial infarction. Methods SD rats were randomly divided into a modeling group and a sham operation group, the rat model with heart failure after myocardial infarction was established by ligaturing the left anterior descending coronary artery in the modeling group, which was randomly divided into a model group, a trimetazidine group, a high, medium and low-dose XFK group, and continuous intragastric administration was treated in each group for 8 weeks, echcardiography was applied to observe the change of cardiac function in rats after 8 weeks. Results Compared with the sham operation group, LVIDd, LVIDs, LVEDV, LVESV in the model group were significantly increased （P 〈 0.01）, while EF, FS, CO decreased significantly （P 〈 0.01）. Compared with the model group, LVIDd, LVIDs, LVEDV, LYESV in the trimetazidine group, the high and low-dose XFK groups were obviously lowered （P 〈 0.05 or P 〈 0.01）, while EF, FS, CO significantly increased （P 〈 0.01）. Conclusion XFK could improve the cardiac function of heart failure after myocardial infarction in model rat.