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长链多不饱和脂肪酸与sflt-1表达在子痫前期的初步研究

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摘要 目的:研究sflt-1mRNA和长链多不饱和脂肪酸(LCPUFA)在子痫前期与正常胎盘组织中表达的差异及其相关性。方法:选取31例子痫前期孕妇(轻度组15例,重度组16例)作为观察组1、组2,随机选取正常妊娠孕妇20例作为对照组,检测各组胎盘组织中sflt-1 mRNA的表达水平并对LCPUFA各组分进行定性及定量分析。结果:(1)sflt-1 mRNA表达水平在组1、组2及对照组分别为3.86±3.49、4.09±4.02、1.39±1.41,观察组与对照组间差异有显著性(P<0.05),观察组间差异无显著性(P>0.05);(2)DHA(n-3族)在组1、组2及对照组含量分别为0.115±0.039、0.108±0.035、0.318±0.035,观察组与对照组间差异有显著性(P<0.05),观察组间差异无显著性(P>0.05);AA(n-6族)在3组中分别为0.181±0.062、0.201±0.066、0.148±0.063,观察组与对照组间均差异有显著性(P<0.05),观察组间差异无显著性(P>0.05);(3)子痫前期孕妇胎盘组织中DHA含量与sflt-1 mRNA的表达成负相关(r=-0.421,P=0.007)。结论:子痫前期孕妇胎盘组织中sflt-1表达升高,可能与胎盘组织中LCPUFA成分的变化特别是DHA的含量的降低有关。
作者 靳艳平 杨祖菁
机构地区 上海交通大学医学院附属新华医院产科
出处 《实用医学杂志》 CAS 北大核心 2013年第17期2834-2836,共3页 The Journal of Practical Medicine
关键词 子痫 SFLT-1 长链多不饱和脂肪酸 气相色谱
分类号 R714.245 [医药卫生—妇产科学]
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参考文献10

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实用医学杂志
2013年 第17期

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