基于肺与大肠相表里的ALI/ARDS证候特征的临床研究

Clinical study of ALI/ARDS syndromes feature based on the theory of the lung and the large intestine being interior-exteriorly related

[目的]在肺与大肠相表里理论指导下,观察肺肠相关在急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)证候表现中的具体形式及其演变规律。[方法]采用临床流行病学调查的方法,收集ALI/ARDS患者127例,于第1天、第3天、第7天3个访视点观察记录临床症状并判断肺与大肠证候类型,采用spearman相关方法,分析证候学资料。[结果]第一访视点:痰热壅盛与肠热腑实正相关。第二访视点:痰热壅盛与肠热腑实正相关;肺气虚与肠燥津亏、肠道气滞正相关、与肠热腑实负相关;肺热炽盛与肠道气滞正相关。第三访视点:痰热壅盛与肠热腑实正相关;肺气虚与肠热腑实负相关;肺阴虚与肠燥津亏正相关。[结论]肺肠相关在ALI/ARDS临床证候中具有特定的表现形式,并随病情发展呈现一定的演变规律,研究结果对深入了解该病病机特征及指导临床具有现实意义。

[Objective] To investigate the specific forms and evolution on the syndromes of correspondence between lung and large intestine in ALI/ARDS, based on the theory which the lung and the large intestine arc interior-exteriorl. [Methods] Using the methods of clinical epidemiology, collect 127 ALI/ARDS patients on the 1st, 2nd and 7th day, and determine the syndromes type of the lung and large intestine, analyzing syndromes information by spearman correlation method, [Results] The first time point, Tanre Yongsheng syndrome and Changre Fushi syndrome are positively correlated. The second time point, Lung-Qi deficiency syndromes were positively correlated with intestine-dryness syndrome and stagnation of intestine-Qi syndrome, meanwhile, it is negatively correlated with Changre Fushi syndrome; syndrome of flaring up of lung heat and stagnation of intestine-Qi yndrome are positively correlated. Tanre Yongsheng syndrome and Changre Fushi syndrome were sitively correlated. The third time point, Lung-Qi deficiency syndrome were negatively correlated with Changre Fushi syndrome; Fei-Yin deficiency syndrome and intestine-dryness syndrome are positively correlated; Tanre Yongsheng syndrome and Changre Fushi syndrome were positively correlated. [Conclusions] Correspondence between lung and large intestine in ALI/ARDS clinical syndrome has specific forms and some kinds of evolution with the illness development, The results of the study have realistic meanings in understanding the disease pathogenesis characteristics and clinical guidance.