天麻钩藤饮加减治疗重度子痫前期的临床评价

Clinical Effect of Tianma Gouteng Decoction in Treating Severe Preeclampsia Patients

目的:评价天麻钩藤饮加减治疗重度子痫前期患者的临床疗效。方法:将80例患者随机按住院前后分为对照组和观察组各40例。两组均采用西医常规治疗,观察组在西医常规治疗的基础上,加用天麻钩藤饮加减,1剂/d,两组疗程均为2～3周。监测患者血压,记录妊娠时间、新生儿体重、1 min Apgar评分(1 min阿氏评分)、母体并发症、围产儿死亡情况,测定24 h尿蛋白定量、血清一氧化氮(NO)及内皮素-1(ET-1)水平。结果:治疗后观察组收缩压(SBP)、舒张压(DBP)低于对照组(P<0.05,P<0.01);观察组终止妊娠时间晚于对照组,新生儿体重重于对照组,母体并发症发生例数少于对照组,1 minApgar评分>7分者多于对照组(P<0.05,P<0.01);治疗后观察组24 h尿蛋白定量低于对照组(P<0.01);治疗后两组NO均明显升高,ET-1明显下低,观察组血清NO水平高于对照组,ET-1水平低于对照组(P<0.01)。结论:天麻钩藤饮加减能控制重度子痫前期患者血压水平,改善症状,延长孕周,改善围产儿结局,并能调节血管内皮功能。

Objective：To discuss the clinical efficacy of Tianma Gouteng decoction in Preeclampsia patients.Method：Eighty patients were randomly divided into observation group（n = 40） and control group（n = 40）.Patients in the two groups were both treated with conventional western therapy.Tianma Gouteng Decoction was used in the observation group（1 dose per day,2-3 as a cycle）.Blood pressure,pregnancy time,birth weight,1 min Apgar score,maternal complications,perinatal mortality,24 h urinary protein excretion,serum nitric oxide（NO） and endothelin-1（ET-1） level were monitored.Result：Systolic blood pressure and diastdic blood pressure of the observation group was lower than the control group（P ＆lt; 0.05,P ＆lt; 0.01）.Termination of pregnancy time of the observation group were late than the control group,birth weight heavier than the control group,cases of the maternal complications were fewer than the control group,member of 1 min Apgar score greater than 7 was more than the control group（P ＆lt; 0.05,P ＆lt; 0.01）;After treatment,24 h urinary protein of the observation group were lower than the control group（P ＆lt; 0.01）;NO level were significantly increased in both groups,ET-1 level of the observation group was significantly lower than the observation group（P ＆lt; 0.01）.Conclusion：Tianma Gouteng decoction can control blood pressure of the patient with severe preeclampsia,improve symptoms,prolong gestational age and improve outcomes of Perinatal Fetus,it also can regulate vascular endothelial function and is worth to further research worthy of clinical use.