早熟中药方治疗特发性性早熟女童临床疗效

To Observe Early Clinical Research of Prescription in Treatment of Ldiopathic Precocious Puberty Girls

目的:观察早熟中药方治疗特发性性早熟(ICPP)女童的临床疗效。方法:对82例ICPP女童用早熟中药方治疗,观察治疗前后中医证候和性腺(乳房大小、子宫、卵巢容积、卵泡直径)以及血清性激素(卵泡刺激素、促黄体生成素、雌二醇)的变化。结果:患儿经过治疗后,中医证候评分、乳房Tanner评分、卵泡直径均较治疗前明显改善,子宫和卵巢容积有不同程度缩小,血清性激素水平也有不同程度的下降。结论:早熟中药方能够降低ICPP女童性激素水平,有效控制和延缓ICPP女童性腺发育的成熟度和速度,而且是治疗ICPP安全、有效的方法。

Objective：To observe the clinical efficacy of precocious prescription in the treatment of idiopathic central precocious puberty（ICPP） girls.Method：Eighty two female patients with ICPP were received the treatment of the precocious prescription.The traditional Chinese medicine syndromes,the change of gonads（breast size,uterine volume,ovarian volume,follicle diameter） and serum sex hormone（follicle stimulating hormone,luteinizing hormone,estradiol） were observed before and after treatment.Result：After treatment,the traditional Chinese medicine syndrome score,the breast Tanner score and the follicle diameter were obviously improved.The volumes of uterine and ovarian were reduced in varying degrees,and the serum sex hormone levels also had different degrees of decline.Conclusion：Precocious prescription can reduce the sex hormone levels of the ICPP girls,and also effectively control and delay the maturity and the speed of gonadal development.It’s a safe and effective method to treat ICPP.