南方地区2型糖尿病患者血清25羟维生素D3的表达及其临床意义

Significance of blood serum 25-hydroxyvitamin D3 in patients with type 2 diabetes mellitus

目的比较南方地区2型糖尿病患者与健康体检者血清25羟维生素D，[25（OH）D，]的浓度，探讨25（OH）D，在2型糖尿病发病中的临床意义。方法选择2型糖尿病患者147例为2型糖尿病组，同期我院健康体检者135例为对照组。采用ELISA法测定血清25（OH）D，浓度，记录一般临床资料并检测相关生化指标，并进行统计分析。结果（1）2型糖尿病组患者血清25（OH）D，浓度较低，但2型糖尿病组和对照组之间以及两组人群男、女性别之间比较差异均无统计学意义[T2DM组为（23．10±1．59）μg/L，对照组（23．11±1．65）μg/L（t=0．064，P=0．949）。T2DM组男、女性患者血清25（OH）D，浓度分别为（23．22±1．54）、（22．95±1．65）μg／L（t=0．209，P〉0．05）。对照组男、女研究对象血清25（OH）D3浓度分别为（23．03±1．73）、（23．18±1．59）μg／L（t=0．436，P〉0．05）；（2）维生素D不足和缺乏的比例在T2DM组比较高，但两组人群之间比较差异无统计学意义（分别为98．0％与94．8％，2．0％与5．2％；x2=2．034，P=0．154）；（3）2型糖尿病患者血清25（OH）D3与甘油三酯呈显著负相关（r=-0．218，P〈0．01）。结论（1）南方地区健康人群和T2DM患者维生素D水平均低下，且维生素D不足和缺乏的比例达90％以上；（2）甘油三酯是T2DM患者的独立危险因子。

Objective To investigate the significance of 25 hydroxyvitamin D3 （25 （OH）D3 ） in patients with type 2 diabetes mellitus by comparing the differences of serum 25-hydroxyvitamin D levels between type 2 diabetes mellitus patients and healthy people. Methods One hundred and forty-seven patients with type 2 diabetes mellitus were selected as the T2DM group, and 135 healthy people were selected as the normal control （NC） group. The level of serum 25 （ OH ） D3 was detected by ELISA . Clinical data were recorded and biochemical indexes were also detected. Statistical analysis was performed. Results （ 1 ） Serum 25 （ OH ） D3 level in T2DM group was low,but there was no significant difference between two groups（ （23.10± 1.59） μg/L vs. （23. 11± 1.65 ）μg/L; t = 0. 064, P = 0. 949 ）, as well as between men and women in the 2 populations （T2DMmenvs. women（23. 22 ±1. 54） μg/L vs. （22.95 ±1.65）μg/L; t =0.209,P〉0.05; NC men vs women （ 23.03± 1.73 ） μg/L vs. （ 23.18 ± 1.59 ） μg/L; t = 0. 436, P 〉 0. 05 ） ; （ 2 ） The prevalence of vitamin D insufficient and deficiency in T2DM group was high, but it was not statistically significant between two groups （98. 0% vs. 94. 8% and 2. 0% vs. 5.2% ; X2 = 2. 034,P = 0. 154） ; （ 3 ） Serum 25 （OH） D3 in T2DM group has a significant negative correlation with triglyeerides （ r = - 0. 218, P 〈 0.01 ）. Conclusion （ 1 ） Vitamin D level was low in both the healthy and T2DM populations in the southern region of China, the prevalence of vitamin D insufficient and deficiency was up to 90%. （2）Triglyceride is the only independent risk factor to T2DM population.