摘要
目的探讨转化生长因子β1（TGF-β1）、血管内皮生长因子（VEGF）、胰岛素生长因子-I（IGF—I）在肺间质纤维化合并肺气肿（CPFE）发病机制中的作用。方法选择2011年7月至2012年2月在我院呼吸内科住院的CPFE患者20例，特发性肺间质纤维化（IPF）患者40例，肺气肿患者40例，ABC-ELISA法测定其血清TGF-β1、VEGF、IGF—I。结果CPFE组和IPF组血清TGF-β1、IGF—I水平均明显高于肺气肿组[TGF-β1：（160．73±40．62）、（167．35±42．82）、（128．75±35．77）ng／L，IGF-I：（179．65±60．73）、（192．32±58．75）、（148．73±49．67）ng／L，P〈0．05或〈0．01]，IPF组血清VEGF水平明显高于肺气肿组[（506．12±82．37）、（437．31±62．58）ng／L，P〈0．01]。CPFE与肺气肿组血清中TGF-β1。与IGF—I呈正相关（r值分别为0．885和0．918，P均〈0．01）。CPFE吸烟组血清VEGF明显低于非吸烟组[（406．19±66．94）、（482．88±79．91）ng／L，t=-2．287，P=0．035]。结论IPF组血清VEGF水平明显升高，推测其参与了肺间质纤维化的形成。TGF—β1与IGF—I存在正线性回归关系，两者在致纤维化的过程中可能起协同作用。
Objective To investigate the levels of transformation growth factor-β1 （TGF-I）, vascular endothelial growth factor （VEGF） and insulin growth factor- I （ IGF- I ） role in the pathogenesis of serum of patients with combined pulmonary fibrosis and emphysema （CPFE）.Methods Recruited 20 patients with CPFE, 40 cases with idiopathic pulmonary interstitial fibrosis （IPF） and 40 cases with emphysema who were admitted to our hospital during July 2011 to February 2012. Serum levels of TGF- β1, VEGF and IGF- I were detected by ABC-ELISA. Results Serum levels of TGF-β1 and IGF- I were significantly higher in patients with CPFE and IPF than these in patients with emphysema （ TGF-131 ： （ 160. 73± 40. 62 ） ng/L vs. （ 167.35 ±42. 82） ng/L vs. （128.75 ±35.77） ng/L; IGF- I ：（179.65 ±80.73） ng/L vs. （192.32±58.75） ng/L vs. （ 148. 73 ±49. 67） ng/L,P 〈0. 05 or P 〈0. 01 ）. The IPF group had significantly higher serum level of VEGF than the emphysema group （ （506. 12±82. 37） ng,/L vs. （437. 31 ±62. 58） ng/L, P 〈0.01 ）. Serum levels of TGF-131 and IGF- Iin CPFE and emphysema groups were positively correlated （r = O. 885,0. 918 respectively, P 〈 O. 01 ）. Smokers in the CPFE group had significantly lower level of serum VEGF than those who did no smoke （（406. 19±66.94） ng/L vs. （482.88±79.91） ng/L, t= -2.287,P=0.035）. Conclusion Serum level of VEGF increased significantly in the IPF group, suggesting the participation of VEGF in pulmonary interstitial fibrosis. IGF- I involved in the pathogenesis of pulmonary interstitial fibrosis. TGF-β1 and IGF- I have a positive linear regressive relationship, which indicates that they may work synergistically in the process of the fibrosis.
出处
《中国综合临床》
2013年第9期929-932,共4页
Clinical Medicine of China
关键词
肺间质纤维化
肺气肿
吸烟
转化生长因子Β1
血管内皮生长因子
胰岛素
生长因子-I
Pulmonary interstitial fibrosis
Emphysema
Smoking
Transformation growth factor-β1
Vascular endothelial growth factor
Insulin growth factor- I
