慢性乙型病毒性肝炎患者抗病毒治疗认知和依从性调查

Survey on the Awareness and Compliance in Patients with Chronic Hepatitis B Receiving Antivi- ral Treatment

【目的】探讨慢性乙型肝炎患者对抗病毒治疗的认知程度及应用抗病毒药物的依从性特点。【方法】采用用药依从性调查表，对180例应用抗病毒药物的门诊就诊慢性乙肝患者进行问卷调查，比较患者不同年龄、文化程度、经济情况、疾病认知程度的用药依从性，分析用药依从性的影响因素。【结果】81．6％的患者能认识到慢性乙型肝炎是一种必须长期治疗的疾病，32．3％的患者能明确抗病毒药物的概念，22．0％的患者知道病毒耐药的概念；调查时点前3个月、6个月、1年及以上患者平均用药依从性为70．9％、57．1％、54．7％。不规则用药的原因分析：70．2％为经济因素，40．5％为对治疗效果不满意；年龄在20～29岁、本科以下学历、经济收入较低的患者，属于治疗依从性差的高危人群。【结论】乙型肝炎患者对抗病毒治疗的认知需进一步提高，用药依从性受多种因素影响，医务人员应依据患者情况设定个体化诊疗方案，在病程中加强用药管理教育和干预。

[Objective]To explore the awareness and compliance features of chronic hepatitis B patients to antiviral treatment and drugs. [Methods] Medication compliance questionnaire was used for the survey of 180 patients with chronic hepatitis ]3 receiving antiviral treatment in clinic service. The age, education level, economic conditions, awareness of the disease and medication compliance among patients were compared. The fac- tors influencing medication compliance were analyzed. [Results] Among all patients, 81.6% of the patients were aware of chronic hepatitis B as a disease to be treated for a long period, and 32.6% of the patients were able to understand the concept of antivirus drugs, and 22.0 % of the patients knew the concept of drug resist- ance. The average medication compliance rate at 3 months, 6 months, one year and over before survey were 70.9%, 57.1% and 54.7%, respectively. The causes of irregular medication were economic factor（70.2%） and dissatisfaction to the treatment effect（40.5%）. Patients who were 20-29 years old and had educational background below undergraduate and low economic income were high-risk population with poor compliance. [Conclusion] The awareness of chronic hepatitis B patients to antiviral treatment should be further improved. Medication compliance is affected by various factors. Medical staff should plan the individualization scheme of diagnosis and treatment. Medication management, education and intervention should be strengthened in the course of the disease.