2型糖尿病动脉血管病变与血小板的关系研究

Study on the Relationship Between Artery Disease and Platelet in Type 2 Diabetes Mellitus

【目的】探讨2型糖尿病（T2DM）不同动脉血管病变中血小板计数（PLT）、血小板平均体积（MPV）及血小板分布宽度（PDW）的变化。[A-法1180例T2DM患者根据踝臂指数（ABI）和颈动脉内膜中层厚度（IMT）分组，单纯ABI≤0．9组（A组）45例，单纯IMT〉0．8mm组（B组）46例，ABI≤0．9且IMT〉0．8mm组（C组）39倒，正常组（ABI〉0．9且IMT≤O．8mm）50例，比较四组的体质量指数（BMI）、糖化血红蛋白（HbAlC）、血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL—C）、PLT、MPV、PDW。【结果】A组、B组和C组的MPV分别为（11．96±0．57）fl；（11．22±1．42）fl；（12．26±0．86）f1，与正常组MPV（9．67±1．56）fl比较，差异有显著性（F=24．69，P〈O．05），C组MPV与A组和B组比较差异无显著性（F值分别为0．09和0．12，P〉0．05）；与正常组比较，各组的PDW和PLT的差异无显著性（F值分别为0．20和0．25，P〉0．05）。【结论】T2DM各种动脉血管病变均与MPV相关，与PDW和PLT数量无关。

Objective To explore the changes of platelet count（Pt）, mean platelet volume（MPV） and platelet distribution width（PDW） in different artery diseases of type 2 diabetes mellitus（T2DM）. EMethodsl According to ankle brachial index（ABI） and carotid artery intima-media thickness（IMT）, 180 T2DM patients were divided into group A（simple ABI≤0.9, n =45）, group B（simple IMT^0.8ram, n =46）, group C（ABI≤0.9 and IMT〉0.8 ram, n =39） and normal control group（ABI〉0.9 and IMT≤0.8mm, n =50）. Body mass index（BMI）, glycated hemoglobin（HbAlc）, total cholesterol（TC）, triglyceride（TG）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C）, Pt count, MPV and PDW were compared among 4 groups. [Results] MPV in group A, B and C was （11.96±0.57）, （11.22±1.42） and （12.26±0.86） respectively, and there was significant difference between group A, B, C and normal group（9.67±1.56）（ F=24.69, P 〈0.05）. There was no significant difference in MPV between group C and group A and B（F=0.09 and 0.12, P 〉0.05）. There was also no significant difference in PDW and Pt count among 4 groups（F=0.20 and 0. 25, P 〉0.05）. [Conclusion] Various artery diseases of T2DM are related to M1DV, but not related to PDW and Pt count.