葡萄球菌性烫伤样皮肤综合征的病原菌及药敏分析

Pathogenic Bacteria and Drug Sensitive Analysis of Staphylococcal Scalded Skin Syndrome

【目的】了解葡萄球菌性烫伤样皮肤综合征（SSSS）患儿病原菌的临床分布及其耐药性，为临床合理用药提供依据。【方法】对2009～2012年4年间湖南省儿童医院SSSS患儿临床分离病原菌的分布及耐药情况进行回顾性分析。【结果1277例SSSS患儿共分离病原菌178株，其中革兰阳性菌166株，金黄色葡萄球菌（sAu）105株，耐甲氧西林金黄色葡萄球菌（MRSA）21株，革兰阴性菌12株。SAU对阿莫西林、阿奇霉素、克林霉素及红霉素耐药率高，对万古霉素和利奈唑烷、呋喃妥因均敏感。甲氧西林敏感金黄色葡萄球茵（MSSA）耐药率明显低于MRSA。【结论】ssss患儿分离的病因菌以SAU为主，儿科应加强对sAU耐药性的监测，并合理选择抗菌药物。

[Objective]To understand the clinical distribution and drug resistance of pediatric patients with staphylococcal scalded skin syndrome（SSSS） so as to provide the basis for clinical rational use of drugs. [Meth- ods] The distribution and drug resistance of pathogens isolated from pediatric patients with SSSS in Hunan Provin- cial Children＇s Hospital from 2009 to 2012 were analyzed retrospectively. [Results]The 178 strains of pathogens were isolated from 277 pediatric patients. There were 166 strains of Gram-positive bacterium including 105 strains of Staphylococcus aureus（SAU） in which 21 strains were methicillin-resistant staphylococcus aureus（MRSA） and 12 strains of Gram-negative bacterium. The resistance rate of SAU to amoxicillin, azithromycin, clindamycin and erythromycin was high. All the strains were sensitive to vancomycin, linezolid and furadantin. The resistance of Methicillin-sensitive Staphylococcus aureus（MSSA） was obviously lower than that of MRSA. [Conclusion] The pathogens isolated from pediatric patients with SSSS are mainly SAU. The monitoring of drug resistance of SAU in pediatric department should be strengthened, and the antibiotics should be chosen rationally.