精神疾病研究进展及转化医学展望

The progresses in psychiatric research and prospects for their translation

精神疾病是一类影响人脑高级功能活动的疾病。异常的感觉、领悟、思维及行为使患者与环境和社会格格不入,严重影响其生活和工作。为了彻底治疗精神疾病,仅靠精神病学家的努力是不够的,也需要非临床科学家的实验研究,并把实验室研究成果转化为临床应用。本文简要评述了近年来精神疾病研究的新进展,并展望它们在未来的可能应用,重点介绍了支持精神分裂症的少突胶质细胞异常学说的临床和实验证据,提出异常的少突胶质细胞应该是治疗精神分裂症的靶标。

Mental illness adversely affects the advanced functions of the human brain. The anomalies in feelings,perceptions,thinking,and actions of subjects not only distort the patterns of their behaviors,but also distress family members and relatives of patients. Overcoming mental disorders is difficult for psychiatrists alone; it also requires experimental research by neuroscientists and the translation of experimental results into clinical practice. This article will briefly comment on the recent advances in psychiatric research and look ahead their translation to clinical practice. The focus of it will be on the clinical and experimental evidence supporting the new hypothesis that schizophrenia involves oligodendrocyte deficits. It w ill conclude w ith a view that altered oligodendrocytes should be one of the targets in the treatment of schizophrenia.