冠心病患者免疫功能临床研究

Clinical study on immune function in patients with coronary heart disease

目的研究冠心病(SHD)患者免疫功能变化情况,探讨免疫因素在冠心病进程的作用。方法以57例冠心病疑似人员为对照,比较180例不同类型冠心病患者免疫功能,并比较冠心病患者治疗前后免疫功能的变化情况。结果细胞免疫中UAP组、AMI组CD3、CD4、CD8均出现下降,CD4/CD8出现上升,与对照组、SAP比较均有统计学差异(P<0.05),体液免疫中UAP组、AMI组IgG、C3、C4出现上升,与对照组、SAP比较均有统计学差异(P<0.05),AMI组IgA出现上升与其他3组比较均有统计学差异(P<0.05);180例冠心病患者治疗后,CD3、CD4、CD8出现不同程度升高,CD4/CD8、IgG、IgA、C3、C4均有不同程度升高与治疗前经t检验比较,均有统计学差异(P<0.05)。结论急性心肌梗死及不稳定性心绞痛均存在不同程度的细胞免疫功能下降及体液免疫功能亢进的现象。

Objective To study the changes of coronary heart disease（SHD）on immune function in patients with coronary heart disease,immune factors in the process of role.Methods 57patients with suspected CAD workers as the control group,compared the immune function in 180patients with different types of coronary heart disease and compared the immune function before and after treatment in patients with coronary heart disease.Results Group UAP,group AMI CD3,CD4,CD8cell immunity decreased,CD4/CD8increased,and the control group,there was significant difference（SAP P0.05）,UAP group,AMI group,IgG,C3,C4appeared in humoral immune to rise,and the control group,there was significant difference（SAP P 0.05）,AMI group IgA increased compared with the other three groups had significant difference（P0.05）;coronary heart disease and 180patients after the treatment,CD3,CD4,CD8increased,CD4/CD8,IgG,IgA,C3,C4were significantly increased in the t test to compare with before treatment,with significant difference（P0.05）.Conclusion acute myocardial infarction and unstable angina pectoris have cellular immune function in varying degrees of decline in immune function and humoral hyperfunction phenomenon.