非小细胞肺癌组织RRM1 mRNA表达及其临床意义

Expression of Ribonucleotide Reductase Subunit M1 mRNA and Its Clinical Significance in Patients with Non-Small Cell Lung Cancer

目的探讨非小细胞肺癌(NSCLC)组织核苷酸还原酶亚基M1(RRM1)mRNA的表达及其临床意义。方法采用逆转录-聚合酶链反应(RT-PCR)检测85例NSCLC患者肺癌组织中RRM1 mRNA的表达。结果 NSCLC组织中RRM1 mRNA阳性表达20例(23.5%),RRM1 mRNA表达与患者年龄、性别、民族、组织类型、病理分级、有无淋巴结转移及TNM分期无关(P>0.05)。结论 RRM1基因的参与了NSCLC的发生过程,但与NSCLC的发展及预后的关系并不明确。

Objective To investigate the expression of ribonucleotide reductase subunit M1（RRM1） and its clinical significance in patients with non-small cell lung cancer（NSCLC）.Methods Reverse transcription-polymerase chain reaction（RT-PCR） was used to detect the expression of RRM1mRNA in tumor tissues of 85 NSCLC patients.Results The positive expression of RRM1mRNA was observed in NSCLC tissues of 20 cases（23.5%）.RRM1mRNA expression did not correlated with patients＇ age,gender,nationality,histological type,pathological grading,the metastasis of lymph node and TNM stages（P 0.05）.Conclusion RRM1 gene involves in the development of NSCLC,but its relationship with the development and prognosis of NSCLC is undefined.