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FGF19、FGF21在巨大儿胎盘组织中的表达差异

Differential expression of FGF19 and FGF21 in placenta of macrosomia
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摘要 目的观察巨大儿产妇胎盘组织中FGF19、FGF21的表达变化,并探讨其在巨大儿发病中的作用。方法采用免疫组化法分别检测30例正常产妇(对照组)和30例巨大儿产妇(研究组)胎盘组织中FGF19、FGF21的表达水平,比较两组的差异性。结果研究组产妇胎盘FGF19表达较对照组明显下降,研究组产妇胎盘FGF21含量明显高于对照组,差异有统计学意义(P<0.05)。结论巨大儿产妇胎盘组织FGF19表达下降,FGF21表达增强,可能与巨大儿的发病有关。 Objective To investigate the changes of FGF19 and FGFE1 in placenta of macrosomia, and to explore the role in the devel- opment of macrosomia. Methods Immunohistochemical method was used to investigate the expression of FGF19 and FGF21 in pla- centa of 30 normal pregnancy （ control group） and 30 cases of macrosomia （ experiment group）. Results Compared with control group, the level of FGF19 in the placenta in experiment group decreased significantly （ P 〈 0.05 ）. The expression of FGF21 in the pla- centa in experiment group was significantly higher than that in control group （ P 〈 0.05 ）. Conclusion The decreased expression of FGF19 and increased expression of FGF21 in placenta may be related to the incidence of macrosomia.
作者 梁迪 王心 尚丽新
机构地区 北京军区总医院妇产科
出处 《山西医科大学学报》 CAS 2013年第8期596-598,F0003,共4页 Journal of Shanxi Medical University
关键词 成纤维细胞生长因子19 成纤维细胞生长因子21 巨大儿 fibroblast growth factor 19 fibroblast growth factor 21 macrosomia
分类号 R714.5 [医药卫生—妇产科学]
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参考文献11

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山西医科大学学报
2013年 第8期

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