系统骨质疏松治疗对老年骨折患者二次骨折发生率与死亡率的影响

Study on the effect of systematic osteoporosis treatment on the incidence of second fracture and mortality in elderly patients with fracture

目的评价系统抗骨质疏松治疗对老年骨质疏松骨折患者2年内二次骨折发生率以及死亡率的影响。方法将2009-2011年之间因骨质疏松骨折来我院骨科治疗的324名患者分为治疗组(n=87)和对照组(n=237)。依据个人情况对治疗组患者进行了系统的抗骨质吸收治疗与补充钙剂治疗,随访6个月-2年,并记录治疗后2年骨质密度、二次骨折发生时间、二次骨折发生率以及死亡率,比较两种处理对患者长期预后的影响。结果经过系统治疗后,治疗组患者第一次骨折后2年内骨折发生率和死亡率均显著低于对照组(P<0.05),骨密度显著高于对照组(P<0.01),二次骨折的发生时间明显晚于对照组患者(P<0.05)。结论系统的抗骨质疏松治疗可明显降低老年骨质疏松骨折患者二次骨折的发生率以及死亡率。

Objective To evaluate the effect of systemic osteoporosis treatment on the incidence of second fracture and mortality in two years after the initial fracture. Methods A total of 324 patients with osteoporotic fracture from 2009 to 2011 were divided into treat- ment group （ n = 87 ） and control group （ n = 237 ） according to their will. Patients in treatment group received individualized systematic osteoporosis treatment and calcium supplementation. Patients in control group received calcium supplementation only or no treatment. Bone density, the time and incidence of second fracture, and the mortality after follow up for two years were recorded and compared be- tween two groups. Results After systematic treatment, the incidence of second fracture and the mortality of patients in treatment group were significantly lower than those in control group （ P 〈 0.05 ）, the bone density （ P 〈 0.01 ） and the interval between two frac- tures （ P 〈 0.05 ） were significantly higher than in control group. Conclusion The incidence of second fracture and the mortality of elderly patients with osteoporotic bone fracture can be significantly reduced by systematic osteoporosis treatment.