滋肾生肝饮治疗肝郁型青春期多囊卵巢综合征的疗效研究

Study on effect of zishenshenggan Decoction for the treatment of liver depression in adolescents with polycystic ovary syndrome

目的探讨中医古方滋肾生肝饮加减治疗肝经郁火型青春期多囊卵巢综合征的临床疗效，探讨性激素结合球蛋白与青春期多囊卵巢综合征发病机制间的关系。方法用中药“滋肾生肝饮”加减方治疗证属肝经郁火型青春期多囊卵巢综合征，3月为1个疗程。分别在治疗前后、月经第3天采集空腹静脉血，对比血清性激素结合球蛋白（SHBG）、睾酮（T）、黄体生成素（LH）、卵泡刺激素（rsH）、雌二醇（E2）等含量，观察月经、中医症候、体重、基础体温（B盯）等变化。结果治疗总有效率64．29％；治疗后月经评分较前下降41．32％，中医症候评分较前下降51．72％，统计学差异具有显著性（P〈0．05）；性激素水平、基础体温、体重指数等方面均得到显著改善（P〈0．05）。结论加减滋肾生肝饮能明显改善肝经郁火型青春期多囊卵巢综合征患者的临床症状，无明显副反应。

Objective Purpose This study is a clinical research of treating liver meridian fermented type of adolescence polycystic ovarian syndrome by using traditional chinese medicine Ancient formula ＂add and subtract zishenshenggan drink＂, and discuss the clinical curative effect of sex hormone b＇mding globulin and adolescence polycystic ovarian syndrome pathogenesis the relationship between them. Methods Take herbal subtract ＂zishenshenggan drinking＂ for three months as a period of treatment. Before the treatment and three months after treatment,gather fasting blood in her menstrual the first three days,Determination of serum sex hormone binding globulin （SHBG）, testosterone （T）, luteinizing hortr^ne （LI-I）, eery follicle - stimulating hormone （FSH）, estradiol （E2）, and the observation of menstruation, TCM symptoms, weight, fundamental temperature （BBT） change. Resuits the total effective rate of 42 cases is 64.29% .After treatment 41.32% meustrual score dropped earlier, TCM symptoms score dropped earlier 51.72% and statistically with significant difference（ P 〈 0.05）.Reproductive hormone levels, fundamental temperature（BBT） ,body mass index（BMI）etc also curative effect is significant（P 〈 0.05）. Conclusion Through this research, confirm ＂add and subtract zishenshenggan drink＂ can significantly improve liver meridian fermented type adolescence polycystic ovarian syndrome patients with clinical symptoms and clinical application no significant side effects and deserves further researeh and extension.