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真核细胞翻译起始因子4E相关通路小分子抑制剂的研究进展

Small molecular inhibitors of eIF4E-related pathways:research advances
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摘要 真核细胞翻译起始因子4E(eIF4E)在蛋白翻译起始过程中发挥重要作用,与肿瘤细胞的生长、增殖和分化等密切相关。随着对eIF4E功能及相关信号通路研究的不断深入,以eIF4E及相关信号通路为靶点的药物在肿瘤治疗中的作用日益引起重视。目前已有部分相关抗肿瘤药物上市或进入临床试验。本文综述了作用于eIF4E及相关通路的小分子抑制剂的研究进展。 Eukaryotic translation initiation factor 4E（eIF4E） plays an important role in protein translation initiation process,and is closely related to tumor cell growth,proliferation and differentiation.With the deepening of study on the function and related signaling pathway of eIF4E,effects of the antitumor drugs targeted eIF4E and related signaling pathway have attracted more and more attention.At present,there are some related antitumor drugs on the market or in clinical trials.This paper reviews the research progress in small molecular inhibitors of eIF4E and its related pathways.
作者 赵兴旺 吴冰 焦慎超 李晶晶 樊印波 刘丽娜 赵睿 李青青 刘丹 赵临襄
机构地区 沈阳药科大学制药工程学院基于结构的药物设计与发现重点实验室
出处 《国际药学研究杂志》 CAS CSCD 2013年第4期396-404,421,共10页 Journal of International Pharmaceutical Research
基金 国家自然科学基金资助项目(81072533)
关键词 真核细胞翻译起始因子4E 小分子抑制剂 作用机制 抗肿瘤活性 eukaryotic translation initiation factors 4E small molecule inhibitors interaction mechanism antitumor activity
分类号 R96 [医药卫生—药理学]
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参考文献57

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二级参考文献27

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国际药学研究杂志
2013年 第4期

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