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氯吡格雷抵抗的检测和治疗策略 被引量：3

Detection and treatment strategy of clopidogrel resistance
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摘要 急性冠状动脉脉综合征和经皮冠状动脉介入治疗的患者应用氯吡格雷治疗后可发生氯吡格雷抵抗,引起血栓事件等严重副作用。血小板功能监测对提高抗血小板治疗效果和预防氯吡格雷抵抗有重要价值。氯吡格雷抵抗的治疗策略包括提高用药剂量、采用三联抗血小板治疗或替换第三代细胞色素P450受体拮抗剂等。本文对血小板功能监测方法和氯吡格雷抵抗的相关治疗策略进行综述。 Patients with acute coronary syndrome or treated with percutaneous coronary intervention may occur clopidogrel resistance,leading to serious side effects such as thrombosis.Platelet function monitoring is of great value to improve the therapeutic effect of antiplatelet and prevent clopidogrel resistance.Treatment strategies of clopidogrel resistance include increasing clopidogrel dose,using triple antiplatelet therapy or replacing the third generation of CYP receptor antagonist.In this paper,platelet function assay method and treatment strategies for the prevention of clopidogrel resistance are reviewed.
作者 王燕慧 裴一璇 张灏
机构地区 甘肃省第二人民医院重症医学科 甘肃省第二人民医院质管科 甘肃省第二人民医院心内科
出处 《国际药学研究杂志》 CAS CSCD 2013年第4期435-438,442,共5页 Journal of International Pharmaceutical Research
关键词 氯吡格雷抵抗 急性冠状动脉综合征 经皮冠状动脉介入治疗 clopidogrel resistance acute coronary syndrome percutaneous coronary intervention
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献20

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同被引文献18

  • 1Vlachojannis G J,Dimitropoulos G,Alexopoulos D.Clopidogrel resistance:current aspects and future directions[J].Hellenic J Cardiol,2011,52(3):236-245.
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  • 6Leoncini M,Toso A,Maioli M,et al.High-dose atorvastatin on the pharmacodynamic effects of double-dose clopidogrel in patients undergoing percutaneous coronary interventions:the ACHIDO(Atorvastatin and Clopidogrel HIgh DOse in stable patients with residual high platelet activity)study[J].JACC Cardiovasc Interv,2013,6(2):169-179.
  • 7韩雅玲,麦晓燕,李毅,张效林,郭亮,闫承慧.细胞色素P450 3A4 894C>T位点基因多态性与氯吡格雷抵抗的关系[J].解放军医学杂志,2008,33(8):939-942. 被引量：14
  • 8赵嫣,屈百鸣,丁亚辉,俞坚武,车贤达.氯吡格雷和他汀联用对急性冠脉综合征患者临床观察[J].心脑血管病防治,2008,8(5):328-329. 被引量：12
  • 9楼永军,王峰,李会林.HPLC-MS测定人血浆中奥美拉唑浓度及药动学[J].中国药学杂志,2010,45(4):292-294. 被引量：7
  • 10耿彦平,谢瑞芹,崔炜,刘凡,杨秀春,张冀东,杨晓红,谷国强,刘静.瑞舒伐他汀和阿托伐他汀对氯吡格雷抗血小板活性的影响[J].中华老年心脑血管病杂志,2011,13(1):27-29. 被引量：15

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国际药学研究杂志
2013年 第4期

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