摘要
EP-1是由炔雌醚和左炔诺孕酮按照1∶2的比例配制而成的一种用于鼠类不育控制的激素类复合不育剂,对鼠类的繁殖及繁殖行为等有一定影响,但对鼠类空间学习与记忆、焦虑行为等非繁殖行为的影响还没有报道。为此,用0(对照)、1.0、2.0、3.0 mg/kg剂量的EP-1对昆明小鼠(Mus musculus)进行灌胃处理,然后用Morris水迷宫和高架十字迷宫分别测定其空间记忆、焦虑行为。结果发现灌胃后15 d,剂量为2.0 mg/kg的EP-1使小鼠空间记忆能力显著下降,但30 d后其空间记忆能力有所恢复,表明2.0 mg/kg剂量的EP-1可以在一定时间范围内降低小鼠的空间记忆能力。但不同剂量的EP-1对小鼠焦虑行为无显著影响。该结果可以为从对非繁殖行为的影响的角度研究EP-1对鼠类的作用提供一定启示。
It has been reported that the EP-1, a contraceptive compound composed of levonorgestrel and quinestrol with the ratio of 1：2, has negative effects on the breeding and reproductive behaviors in some species of mice and rats. However, little is known that the effects of EP-1 on spatial memory and anxiety in mice. Here, the effects of treatment time （15 d and 30 d） and dose （0 mg/kg （control）, 1.0 mg/kg, 2.0 mg/kg, 3.0 mg/kg） of EP-1 on spatial memory and anxiety in Mus musculus were tested using Morris water maze and elevated plus maze separately. Negative effects of 2.0 mg/kg EP-1 on spatial memory of the subjects were found in 15 days, and this ability recovered in 30 days, implying the 2.0 mg/kg EP-1 can decrease the ability of spatial memory of M. musculus within a period of time. No significant effects were found in all treatments of time and dose of EP-1 on anxiety of the subjects. The results might help to evaluate the effects of EP-1 on mice in respect to non-reproductive behaviors.
出处
《生态学报》
CAS
CSCD
北大核心
2013年第17期5228-5233,共6页
Acta Ecologica Sinica
