转录因子GATA-2在早期造血过程中的作用(英文)

The Role of Transcription Factor GATA-2 in Early Hematopoiesis

转录因子GATA 2是GATA家族的一成员 ,以其锌指结构结合于 [(T/A(GATA)A/G]的共同DNA序列结构。近期 ,通过敲除小鼠GATA 2基因的实验证明了GATA 2在造血细胞发育中的重要地位。GATA 2基因断裂导致全部造血祖细胞的减少 ;相反 ,强制表达GATA 2则阻止正常造血。GATA 2的调节作用发挥于早期胚胎时期并与其它的GATA转录因子共同作用于粒系、红系、巨核系和肥大细胞系等的增殖和分化过程中。在人髓系白血病细胞株和大多数白血病病人中能检测到GATA 2的mRNA和蛋白。虽然有资料显示GATA 2能转化Cas Br E和 graffi逆转录病毒 ,后者可诱导小鼠发生白血病 ,但GATA 2在白血病发生中的作用仍不明确。

Transcription factor GATA-2 is a member of GATA family which binds a common DNA sequence motif [T/A (GATA) A/G] through an evolutionarily conserved zinc finger domain. An essential role for GATA-2 in the development of hematopoietic cells has recently been shown in gene knockout experiments in mice. GATA-2 gene disruption makes reduction in all hematopoietic precursors, whereas enforced expression of GATA-2 blocks normal hematopoiesis. GATA-2 exerts regulation in early embryo and cooperates with other GATA transcription factors in proliferation and differentiation of myeloid, erythroid, megakaryocytic and mast cell lineages. GATA-2 mRNA and protein could be detected in human myelogenous leukemia cell lines and in most patients with primary leukemias. Some data revealed that GATA-2 could transactivate the Cas-Br-E and graffi retroviruses, which can induce myelogenous leukemia in mice. However, the role of GATA-2 in pathogenesis of leukemia is still not well understood.