骨髓增生异常综合征基因缺陷的研究

Study on Gene Defects in Myelodysplastic Syndrome

骨髓增生异常综合征是一种造血干细胞克隆异常性疾病。近代分子遗传学的发展使我们对其分子水平上的形成机制有了进一步的了解。本文主要从原癌基因的异常表达、肿瘤抑制基因表达的缺失和DNA修复机制的异常等方面概括地论述了骨髓增生异常综合征基因缺陷的研究进展。

Myelodysplastic syndrome (MDS) is a clonal disorder of the hematopoietic stem cell. Recent developments in molecular genetics have provided insights into the molecular mechanisms that lead to MDS. This review summarizes the most recent developments in the understanding of the gene defects associated with MDS which mainly include altered expression of oncogenes, the loss of expression of tumor suppressor genes and the repair of DNA.