HBV母婴宫内垂直传播与新生儿脐带血淋巴细胞染色体畸变相关性

CORRELATION BETWEEN VERTICAL TRANSMISSION OF HBV IN UTERUS AND CHROMOSOMAL ABERRATION OF CORD BLOOD LYMPHOCYTES

目的了解本地区乙型肝炎病毒(HBV)感染孕妇母婴垂直传播状况,探讨HBV先天性感染与新生儿脐带血淋巴细胞染色体畸变的相关性。方法选取83例HBV感染产妇及20例正常产妇,检测其新生儿脐带血HBsAg,并对其脐带血淋巴细胞染色体进行核型分析。结果在83例HBV感染产妇分娩新生儿中,41例检出HBsAg,宫内感染率为49.4%;41例先天性感染新生儿脐带血淋巴细胞染色体均发生畸变,11例畸变率>5%;42例未感染者中69%的染色体发生畸变,7例畸变率>5%;20例正常对照者中70%的染色体发生畸变,畸变率均<3%,两组畸变率比较差异有显著性(χ2=27.03,P<0.01)。结论 HBV感染孕妇胎儿获得宫内感染的风险较高,HBV先天性感染可导致新生儿脐带血淋巴细胞染色体畸变风险增加且畸变率上升。

Objective To investigate the status of maternal-infantile vertical transmission of HBV from a HBV positive mother to her child, and explore the correlation between its infection and chromosome aberrations （CB） of cord blood lymphocytes （CBLs）. Methods Eighty-three HBsAg-positive and 20 HBsAg-negative lying-in women were enrolled in this study. HBsAg in cord blood was detected in their infants, and a karyotype analysis was done for chromosomes of CBLs. Results HBsAg was de- tected in 41 （49.4%） neonates, and all of these 41 cases were found with CBLs, the aberration rate of 〉5% was noted in 11 cases; 42 born with HBsAg negative, of whom, CBLs were noted in 70%, the aberration rate was 〉5% in seven cases; in 20 normal controls, CBLs was noted in 70%, the aberration rate was 〈3%, the differences of aberration rates between the two groups were significant （χ2=27.03,P〈0.01）. Conclusion The risk of intrauterine HBV infection in fetus is relatively high from a HBV-po- sitive mother, congenital HBV infection can increase the risk of chromosome aberrations of cord blood lymphocytes thus raise the aberration rate.