Survivin、Fas在宫颈癌中的表达及意义

Expressions of Survivin and Fas in Cervical Carcinoma and Their Significance

[目的]探讨Survivin、Fas在宫颈癌组织中的表达及其与临床病理因素之间的关系。[方法]采用免疫组织化学SP法分别检测30例宫颈癌组织、25例宫颈上皮内瘤变组织、16例正常宫颈组织中Survivin、Fas的阳性表达情况,分析宫颈癌组织中Survivin、Fas的阳性表达与各临床病理因素之间的关系。[结果]Fas在正常宫颈组织中高表达,而在宫颈癌组织中低表达;Survivin在正常宫颈组织中不表达,而在宫颈癌组织中高表达;两者在宫颈不同病变中的表达差异均有统计学意义(P<0.05)。Survivin的表达与宫颈癌临床分期有关;Fas的表达与病理分级、临床分期以及是否淋巴结转移有关。宫颈癌中Survivin和Fas的阳性表达呈负相关(r=-0.408,P=0.025)。[结论]Survivin高表达和Fas低表达可以引起细胞凋亡的抑制,在宫颈癌的发生发展中起一定作用。降低Survivin表达和提高Fas表达可望成为治疗宫颈癌的新靶点。

[Purpose] To investigate the expressions of Survivin and Fas in cervical cancer tis- sues and the relationship with clinical pathological factors. [Methods] Expressions of Survivin and Fas were detected by immunohistochemical technology SP detection method in 30 patients with cervical cancer,25 patients with cervical intraepithelial neoplasia and 16 healthy controls. The relationship between positive expression of Survivin and Fas in cervical cancer tissues and clinical pathological factors was analyzed. [Results ] Fas was highly expressed in the normal cer- vical tissues and lowly expressed in cervical cancer tissues; while Survivin was negative expres- sion in normal cervical tissues and highly expressed in cervical cancer tissues,with significant difference （P〈0.05）. Survivin expression correlated with clinical staging,while Fas expression correlated with grade,clinical staging and lymph node metastasis. Survivin expression and Fas expression showed negative correlation （r=-0.408 ,P=0.025）. [Conclusion] High expression of Survivin and low expression of Fas may induce apoptosis inhibition, and they may play roles in carcinogenesis and progression of cervical cancer. Downregulating Survivin expression and up- regulating Fas expression maybe become new targets in the treatment for cervical cancer.