肠易激综合征与抑郁、焦虑障碍的关系

Relationship between irritable bowel syndrome and depression/anxiety disorders

目的:探讨肠易激综合征(IBS)与抑郁、焦虑的关系。方法:采用美国精神障碍手册第4版(DSM-IV)轴I为诊断标准的临床结构式访谈工具(SCID-I-P)、抑郁自评量表(SDS)、焦虑自评量表(SAS)对126例IBS患者(IBS组)进行评估,并与126名正常对照者(对照组)比较。结果:IBS组的SDS、SAS标准分显著高于对照组(P均<0.001);IBS组抑郁/焦虑障碍发生率为4.76%(6例),其中1例IBS发病前诊断为焦虑障碍;抑郁和/或焦虑状态的发生率(52.4%,66例)明显的高于对照组(34.9%,44人)(P<0.01)。结论:IBS不是焦虑或抑郁障碍的延续,抑郁和/或焦虑障碍的发生与IBS密切相关。

Objective：To explore the relationship between irritable bowel syndrome （IBS） and depression/anxiety disorders.Method：The structured clinical interview Axis I disorders （SCID-I-P） of manual of mental disorders IV （DSM-IV）,self-rating anxiety scale（SAS） and self-rating depression scale（SDS） were used to assess the depression and anxiety disorders in 126 patients with IBS（IBS group）,the results were compared with 126 healthy controls（control group）.Results：The standard scores of SDS and SAS in IBS group were significantly higher than control group（all P0.001）.The incidence of depression/anxiety disorder in IBS group was 4.76%（6 cases）,only 1 case diagnosed anxiety disorder was prior to the onset of IBS.The incidence of depression and/or anxiety state in IBS group （52.4%,66 cases）was significantly higher than control group （34.9%,44 cases）（P0.01）.Conclusion：IBS is not the continuation of depression/anxiety disorder,but occurrence of depression/anxiety is closely associated with IBS.