不同剂量奥氮平治疗精神分裂症的疗效及对患者糖、脂代谢的影响

Curative effect and influence on glucose and lipid metabolism of olanzapine with different doses in patients with schizophrenia

目的:探讨不同剂量奥氮平治疗精神分裂症的疗效及对患者糖、脂代谢的影响。方法:96例精神分裂症患者随机分为奥氮平低剂量组(50例,<10mg/d)和高剂量组(46例,>10mg/d);分别于治疗前、治疗2、4、8周末采用阳性与阴性症状量表(PANSS)进行评分,并检测体质量指数(BMI)、血糖及血脂;8周末评价疗效。结果:低剂量组和高剂量组起效时间和疗效比较差异无统计学意义;与治疗前相比,8周末低剂量组总胆固醇明显增高(P<0.05);高剂量组BMI、血糖、总胆固醇和甘油三酯明显增高(P<0.05或P<0.01)。结论:奥氮平治疗精神分裂症的剂量范围内,低剂量和高剂量起效时间及疗效相当,但均可影响脂代谢;高剂量对血糖、血脂代谢的影响更明显。

Objective：To explore the curative effect and influence on glucose and lipid metabolism of olanzapine with different doses in patients with schizophrenia.Method：Ninety-six patients with schizophrenia were randomly divided into olanzapine low dose group（50 cases,10 mg/d）and high dose group（46 cases,10 mg/d）.The assessment of positive and negative syndrome scale （PANSS） was preformed,the body mass index （BMI） was measured and the blood glucose and blood lipid were detected before treatment and after 2,4,8 weekends,respectively.After 8 weeks,curative effect was evaluated.Results：The reacting time and the curative effect in the two groups were no significantly difference.Compared with before treatment,the level of total cholesterol in lower dose group was significantly increased （P0.05）;BMI,the levels of blood glucose and blood lipid in high dose group were significantly increased at 8 weeks after treatment（P0.05 or P0.01）.Conclusion：In the therapeutic dose range,olanzapine with low does or high does can make equal reacting time,curative effect and affecting blood lipid metabolism in patients with schizophrenia;High dose is more obvious influence on blood sugar and blood fat metabolismcan.