阿立哌唑对抗精神病药物所致的老年精神分裂症患者高催乳素血症的影响

Influence of aripiprazole on hyperprolactinemia caused by antipsychotics in elderly patients with schizophrenia

目的:探讨阿立哌唑对抗精神病药物所致的老年精神分裂症患者高催乳素血症的影响。方法:63例抗精神病药所致高催乳素血症的老年精神分裂症患者随机分为研究组(33例)和对照组(30例)。两组沿用原有抗精神病药物,研究组加用阿立哌唑5mg/d持续12周。分别于入组前、入组4、8、12周末检测血清催乳素水平,同时采用简明精神病评定量表(BPRS)和治疗中出现的症状量表(TESS)评定精神病性症状及药物不良反应。结果:入组4、8、12周末研究组血清催乳素水平较入组前及对照组显著降低(P均<0.05);对照组入组前后血清催乳素水平差异无统计学意义(P均>0.05)。两组入组前后BPRS、TESS评分差异无统计学意义(P均>0.05)。结论:阿立哌唑可有效降低抗精神病药物所致老年精神分裂症患者血清催乳素水平增高,且并未增加药物不良反应。

Objective：To explore the influence of aripiprazole on hyperprolactinemia caused by antipsychotics in elderly patients with schizophrenia.Method：Sixty-two elderly schizophrenia patients with hyperprolactimia caused by antipsychotics were randomly divided into the study group （33 cases） and the control group （30 cases）.On the basis of using original antipsychotic drugs,study group was received 5 mg/d aripiprazole as a combination treatment for 12 weeks.The level of serum prolactin （PRL） was detected,the psychotic symptoms and adverse reactions were assessed by brief psychiatric rating scale （BPRS） and treatment emergent symptom scale（TESS） before into the group and 4,8,12 weekend into the group,respectively.Results：At 4,8,12 weekend after into the group,the levels of PRL in study group were significantly decreased than before into the group and control group （all P0.05）.While,which was no significant difference in control group between before and after into the group （all P0.05）.The scores of BPRS and TESS between the two groups were no significant differences at each time point.Conclusion：Aripiprazole can effectively reduce the level of serum PRL whose increase caused by antipsychotic drugs in elderly schizophrenia patients and does not increase adverse drug reaction.