PTEN、p21基因在新疆哈萨克族食管癌中的表达

Expressions of PTEN and p21 Genes in Hazak Patients with Esophageal Cancer

目的研究PTEN、p21基因在哈萨克族食管癌中的表达。方法采用RT-PCR法检测PTEN、p21基因在48例哈萨克族食管癌组织及远端无癌组织中的表达,并分析其表达与肿瘤分化、TNM分期、临床分期、淋巴结转移的关系。结果 PTEN基因在癌组织和远端无癌组织中的表达阳性率分别为75%、45.8%,癌组织高于远端无癌组织(χ2=8.537,P<0.05);p21基因在癌组织和远端无癌组织中表达的阳性率分别为95.8%、97.9%,差异无统计学意义(χ2=0.344,P>0.05)。PTEN和p21表达与食管癌分化程度、不同浸润深度及有无淋巴结转移均无相关性。结论 PTEN、p21基因可能均不是哈萨克族食管癌的主要致病基因。

Objective To investigate the expressions of PTEN and p21 genes in Hazak patients with esophageal cancer. Methods The expressions of PTEN and p21 genes were detected by RT-PCR in 48 samples （cancer tissues and normal tissues） of patients with esophageal cancer. The relationship between the expressions of PTEN and p21 genes, tumor differentiation, TNM stage, clinical phase and lymph node metastasis were analyzed. Results The positive rates of PTEN gene were 75% and 45.8% in cancer and distant normal tissues. The expression of PTEN was significantly higher in cancer tissues than that of distant normal tissues （X%8.537, P 〈 0.05）. The positive rates of p21 gene were 95.8% and 97.9% in cancer and distant normal tissues, and no significant difference between them （x^2=0.344, P 〉 0.05）. There was no correlation between expressions of PTEN and p21and the tumor differentiation, the depth of invasion and lymph node metastasis in esophageal cancer. Conclusion PTEN and p21 genes are not the primary genes for the carcinogenesis of esophageal cancer in Hazak.