ACS患者血浆MMP-9及hs-CRP水平与冠状动脉病变的相关性

Correlation between MMP-9,hs-CRP levels and coronary lesion in patients with acute coronary syndrome

目的:探讨急性冠状动脉综合征(ACS)患者外周血浆基质金属蛋白酶-9(MMP-9)、超敏C反应蛋白(hs-CRP)水平与冠脉病变的相关性。方法:选择ACS患者60例,其中急性心肌梗死(AMI)30例(AMI组),不稳定型心绞痛(UAP)30例(UAP组);另选同期住院的稳定型心绞痛(SAP)30例(SAP组)及非冠心病患者30例(对照组);采用酶联免疫吸附(ELISA)法分别测定各组患者外周血浆MMP-9及hs-CRP水平,并与冠状动脉造影Gensini积分行相关性分析。结果:各组血浆MMP-9与hs-CRP水平均差异有统计学意义,其中AMI组>UAP组>SAP组>对照组(均P<0.05);与对照组比较,AMI组、UAP组及SAP组Gensini评分均增大(均P<0.05);血浆MMP-9水平与hs-CRP水平呈显著正相关性(r=0.881,P<0.05),血浆MMP-9水平与Gensini评分之间无相关性(r=0.392,P>0.05)。结论:急性ACS患者血浆MMP-9和hs-CRP水平可以预测冠状动脉病变的稳定性,但不能预测病变程度。

Objective： To investigate the correlation between serum matrix metalloproteinase-9 （MMP-9）, high-sensitivity C-reactive protein （hs-CRP） levels and coronary lesion in patients with acute coronary syndrome （ACS）. Method：Sixty cases with ACS were chosen in this trial, including 30 cases with acute myocardial infarction （AMI group） and 30 cases with unstable angina pectoris （UAP group）. While 30 cases with stable angina pectoris （SAP group） and 30 cases without CHD （control group） also were included. MMP-9 and hs-CRP levels were determined by enzyme-linked immunosorbent assay （ELISA）, and the correlation between the level of MMP-9, hs CRP and coronary angiography Gensini score were analyzed respecttively. Result： The four groups showed significant differences in plasma MMP-9 and hs-CRP levels each other （all P〈0.01）. There was no statistical difference among AMI group, UAP group and SAP group in Gensini score. Compared to control group, all the other three groups were higher in Gensini score （all P〈0.01）. There was a significant positive correlation between MMP-9 level and hs-CRP level （r=0.881, P〈0.05）, and no correlation between MMP-9 level and Gensini score （r=0.392, P〈0.05）. Conclusion： MMP-9 can predict the stability of coronary lesions in patients with ACS, but it can not predict the degree of coronary artery lesions.