白细胞介素-38及其相关细胞因子在炎症中的作用

Role of Interleukin-38 and Its Related Cytokines in Inflammation

白细胞介素(interleukin,IL)-38是最近发现的IL-1家族细胞因子的第10个成员。IL-38的基因序列与IL-1受体拮抗剂(IL-1Ra)和IL-36Ra的基因有较高的同源性。IL-38的特异性受体为IL-36R,它是IL-36的部分受体拮抗剂。IL-38可抑制Th17细胞产生IL-17和IL-22等炎症介质,也可抑制IL-36γ诱导产生IL-8,从而抑制炎症反应。该文对IL-38的生物学特征、受体与信号通路、生物学活性及其相关细胞因子作一综述。

Interleukin （IL）-38 is the most recently discovered cytokine, which is the tenth member of IL-1 cytokine family. IL-38 shares a high homology with IL-1 receptor antagonist （IL-1Ra） and IL-36Ra. IL-36R is the specific receptor of IL-38 which is the partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokine IL-17 and IL-22. IL-38 also can inhibit the production of IL-8 which is induced by IL-36γ, thus inhibiting inflammatory response. This review will introduce the biological characteristics, receptor and signal pathway, biological activity of IL-38 and its related cytokines.