肾上腺皮质细胞模型研究进展

Progress of research in adrenal cortical cells model

本文主要介绍了人、小鼠肾上腺皮质癌细胞系生物学特性，以及原代培养的大鼠、牛肾上腺皮质细胞研究进展。比较了不同人肾上腺皮质癌细胞系及细胞株对血管紧张素Ⅱ、钾离子、促肾上腺皮质激素等的应答作用，及其所分泌的类固醇激素差异。认为发展与建立理想肾上腺皮质细胞模型是深入研究类固醇激素合成与分泌机制的重要工具。

[ Summary] This paper describes the biological characteristics of human and mouse adrenal cortical carcinoma cell lines and presents research progress made in rat and bovine primary cuhured adrenal cortical ceils. The effect of angiotensin If, potassium, adrenocorticotropic hormone and cAMPon different adrenal cortical cell lines were compared and analyzed, regarding the differences of steroid hormone secreted. The article suggests that it is necessary to develop and establish some ideal adrenal cortex ceil models for furtherstudying the mechanisms of steroid hormone synthesis and secretion.