多胎妊娠早产儿191例ROP筛查结果分析

Outcomes of retinopathy of prematurlty screening in 191 multiple pregnancy premature infants

目的观察多胎妊娠早产）LROP的发生情况，探讨相关危险因素。方法191例多胎妊娠早产儿纳入研究，所有患儿均由经验丰富的视网膜专科医师用二代广角数码视网膜成像系统（RetCamI／）进行检查，研究早产儿视网膜病变（Retinopathyofprematurity，ROP）的发生率及其与胎龄、出生体重、分娩方式及有无吸氧史的关系。应用SPSS17．0统计软件分析结果。结果191例多胎妊娠早产儿ROP发生率9．95％（19／191），发现ROP征象的19例患儿有明确吸氧史者16例。双胎妊娠ROP发生率8．79％（16／182）；三胎妊娠ROP发生率33．33％（3／9）；顺产100例8例发现ROP，剖宫产91例11例发现ROP；19例ROP患儿平均出生体重（1．47±0．45）kg，无ROP的172例早产儿平均出生体重（1．90±0．45）kg，两组出生体重比较具有统计学意义（t=3．91．P=0．0001）；19例ROP患儿出生时胎龄平均（29．53±2．25）周，未出现ROP的172例早产儿乎均胎龄（32．93±2．93）周，两组出生胎龄比较具有统计学意义（t=6．75，P〈0．0001）。结论多胎妊娠早产儿ROP发生率较高，胎龄、出生体重是ROP发生的重要危险因素。

Objective To observe the occurrence of multiple pregnancy premature ROP （Retinopa- thy of prematurity, ROP）, and to discuss the related risk factors. Methods Of 191 cases of multi- ple pregnancy premature included in the study, fimdus examinations were performed with Retcam II, the incidence of the ROP and and its relationship with related risk factors were studied. The SPSS 17.0 software was applied in the statistical analysis. Results The incidence of ROP was 9.95% （19/ 191） in 191 cases of multiple pregnancy premature, twins was 8.79% （16/182）; triplets were 33.33% （3/9）. The average birth weight of 19 infants with ROP was （1.47±0.45） kg, 172 cases without ROP was （1.90±0.45） kg, birth weight between two groups had statistical significance （t =3.91, P = 0.0001）; The average born age of 19 infants with ROP was （29.53 ±2.25） weeks, 172 cases without ROP was （32.93±2.93） weeks, between the two groups, born age had statistical significance （t = 6.75, P 〈0.0001）. Conclusions The incidence of ROP with multiple pregnancy premature is higher, gestational age and birth weight are important risk factors for ROP.