过氧化物酶体增殖物激活受体δ激动剂在肾小管上皮细胞炎性反应中的作用
摘要
过氧化物酶体增殖物激活受体（PPARs）有3种异构体：PPARα、PPAR8和PPARr、作为转录N子的PPARs，通过酬前特定的目的基因的表达，影响脂代谢、糖代谢稳念、细胞分化、免疫反应、炎性反应和肿瘤等[1-2]。
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2013年第7期538-539,共2页
Chinese Journal of Nephrology
参考文献9
-
1Dreyer C, Krey G, Keller H, et al. Control of the peroxisomal beta-oxidation pathway by a novel ihmily of nuclear hormone receptors. Cell, 1992, 68: 879-887.
-
2Gervois P, Fruchart JC, Staels B. Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator- activated receptors. Nat Clin Pratt Endocrinol Metab, 2007, 3: 145-156.
-
3lsshiki K, Haneda M, Kuya D, et al. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. Diabetes, 2000, 49: 1022-1032.
-
4Park CW, Zhang Y, Zhang X, et al. PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int, 2006, 69:1511-1517.
-
5Takaya K, Koya D, lsono M, et al. Involvement of ERK pathway ira albumin- indtwed MCP- 1 expression in mouse proximal tubular cells. Am J Physiol Renal Physiol, 2003, 284: F1037- F1045.
-
6Barish GD, Atkins AR, Downes M, et al. PPARdelta regulates multiple proinflammatory pathways to suppress atheroselerosis. Proc Natl Acad Sci USA. 2008. 105: 4271-4276.
-
7Bishop- Bailey D, Bystrom J. Emerging roles of peroxisome proliferator - activatedreceptor - beta/deha in inflammation. Pharmaeol Ther, 2009, 124: 141- 150.
-
8Yang X, Kume S, Tanaka Y, et al. GW501516, a PPARδ agonisl, ameliorates lubulointerstitial inflammalion in proteinurie kidney disease via inhibition of TAKI- NFKB pathway in mice. PLoS One, 2011, 6: e25271.
-
9Schnegg CI, Kooshki M, Hsu FC, et al. PPARδ prewmts radiation- induced proinflammatory responses in microglia via transrepression of NF-KB and inhibition of Ihe PKCct/MEKI/2/ ERKI/2/AP-1 pathway. Free Radio Biol Med, 2012, 52: 1734- 1743.
-
1王龙飞,谈敏,常虹,余华,沈际佳.过氧化物酶体增殖物激活受体δ＋294T／C基因多态性与冠心病的关系[J].安徽医科大学学报,2008,43(6):701-705. 被引量：1
-
2计妙锦,余旭奔,洪浩.过氧化物酶体增殖物激活受体δ与中枢神经系统疾病[J].中国基层医药,2014,21(14):2214-2217.
-
3宋欢欢,徐尚华,黄茂芝,许昌声,谢良地.过氧化物酶体增殖物激活受体δ对同型半胱氨酸诱导人脐静脉内皮细胞MCP-1 mRNA表达的影响及机制[J].中国病理生理杂志,2012,28(2):222-227. 被引量：5
-
4陈明亮,易龙,金鑫,谢琦,周曦,陈春烨,张婷,王丽,糜漫天.白藜芦醇对TNF-α诱导的血管内皮细胞炎性反应的影响[J].第三军医大学学报,2012,34(13):1255-1258. 被引量：12
-
5姜友昭,张玲,周艳,陈兵.小鼠PPARδ腺病毒载体的构建及其在INS-1细胞中的表达[J].第三军医大学学报,2007,29(1):68-70. 被引量：3
-
6张莉莉,祝之明,曹廷兵,王利娟.Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα[J].Journal of Medical Colleges of PLA(China),2006,21(2):77-81. 被引量：2
-
7章涛,袁野,李苌清,杨俊卿,周元国,周岐新.人PPARδ受体cDNA全长序列的克隆及测序[J].重庆医科大学学报,2007,32(8):789-791.
-
8于晓静,苏本利,王晓梅,金成吉,曲健梅,冯海娟.糖代谢相关指标与PPARδ-87T/C基因多态性的关系研究[J].中国糖尿病杂志,2007,15(10):596-597. 被引量：1
-
9龙春燕,张莉莉,孙梦娇,黎炳护,皮燕,郭露,曹小洁,尹延伟,廖少琼,李敬诚.PPARδ通过下调ACAT1抑制血管平滑肌细胞泡沫样变[J].第三军医大学学报,2015,37(18):1801-1805.
-
10苏丽,姜宁,张玥,牛燕媚,苑红,席翼,张勇,傅力.有氧运动对C57BL／6小鼠骨骼肌PPARδ表达和肌纤维类型的影响[J].中国运动医学杂志,2008,27(1):27-31. 被引量：7
