甲状腺疾病患者乳汁与血清中甲状腺激素水平的关系

Relationship between Maternal Milk and Serum Thyroid Hormones in Patients with Thyroid Related Diseases

目的研究甲状腺疾病患者的母乳与血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)和促甲状腺激素(TSH)的关系。方法留取56例受试者60份母乳样本及其血清,测定FT3、FT4、T3、T4和TSH水平。以血清甲状腺激素为自变量,母乳中甲状腺激素为因变量进行直线回归分析。结果母乳FT3、FT4、T3、T4、TSH和T3/T4水平分别为(2.30±0.82)pg/ml、(0.45±0.26)ng/dl、(0.35±0.20)ng/ml、(2.96±1.55)μg/dl、(0.12±0.08)μU/ml和0.12±0.04。血清与母乳中FT3(r=0.778,P=0.000)、T3(r=0.603,P=0.000)、T4(r=0.485,P=0.004)和TSH(r=0.605,P=0.000)水平呈显著正相关。FT3、FT4、T3、T4和TSH的透过率分别为78%、32%、26%、30%和8%。结论母乳中存在甲状腺激素,母乳与血清中的甲状腺激素水平呈正相关。

Objective To explore the relationship between maternal milk and serum thyroid hormones in patients with thyroid-related diseases. Methods Serum and breast milk samples were collected from 56 breastfeeding mothers. Milk and serum free triiodothyronine （ FT3 ）, free thyroxine （ FT4 ）, triiodothyro- nine （ T3 ）, thyroxine （ T4）, and thyrotrophin （TSH） were determined, and T3/T4 was calculated. Using the serum thyroid hormones as the independent variables and milk thyroid hormones as the dependent variables, we performed linear regression analysis. Results The milk FT3, FT4, T3, T4, TSH, and T3/T4 were （2.30±0.82） pg/ml, （0.45±0.26）ng/dl, （0.35±0.20）ng/ml, （2.96±1.55）μg/dl, （0.12± 0.08） μU/ml, and0.12±0.04, respectively. Milk FT3 （r=0.778, P=0.000）, T3 （r=0.603, P= 0. 000）, T4 （r = 0. 485, P = 0. 004）, and TSH （r = 0. 605, P = 0. 000） concentrations were positively cor- related with those in serum. Conclusion Thyroid hormones are present in human milk and are positively eorrela-ted with those in serum.