摘要
青蒿素及其衍生物是一类天然的抗恶性疟疾特效药,近来研究显示其可通过阻滞细胞周期、诱导细胞凋亡、抗血管生成、调节肿瘤相关基因的表达以及损伤细胞线粒体等发挥抗肿瘤作用,但具体机制尚不清楚。
Artemisinin and its derivatives are highly effective in fighting against malaria. Notably, these drugs have shown potent anti-timor activities by arresting cellular growth, enhancing apoptosis, inhibiting anglo- genesis, and regulating the expression of tumor-associated genes, although the underlying mechanisms remain unclear.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2013年第4期466-471,共6页
Acta Academiae Medicinae Sinicae
关键词
青蒿素
抗肿瘤
衍生物
artemisinin
antitumor activity
derivatives
