2008--2012年阿尔茨海默病国内外文献分布和研究状况分析

Research status of literatures on Alzheimer disease published at home and abroad from 2008 to 2012

目的分析国内外近年来阿尔茨海默病（AD）的文献分布和研究状况，比较国内外研究文献差异，为阿尔茨海默病研究提供文献计量学资料。方法通过Pubmed数据库和万方数据库国内核心期刊，应用文献计量方法，检索主题词中含有阿尔茨海默病，并细化检索条件，从文献外部特征和文献内容对2008--2012年关于AD研究的文献进行统计学分析，主要分析国内外AD研究的文献类型、期刊分布，重点分析比较国内外目前AD研究文献中的热点高频词。结果符合检索条件的国内文献646篇，Pubmed数据库19423篇。国内论著类以临床研究较多，基础研究和流行病学研究较少。国内核心期刊的AD学科分布与国外类似，主要是神经、脑和老年医学期刊。国内AD研究论文在Pubmed中收录的不到5％，部分国内期刊中文或英文版在Pubmed文献收录中占一定比例。国内外近年研究方向有些方面较接近，如淀粉样蛋白、诊断、基因等；但国外对AD的代谢、影像、衰老机理比较重视，国内对胆碱类药物、tau蛋白、海马和中医治疗有相当多的文献报道。结论近5年国内与国外AD期刊学科分布相对固定，我国AD研究方向与国外有接近的方面，但某些方向滞后，国内需加强AD基础和流行病学的研究。

Objective To explore the distribution and research status of literatures on Alzheimer disease （AD） published recently, to compare the differences in the research papers on AD between China and foreign countries, and to provide bibliometrics data for Alzheimer disease research. Methods Using bibliometries methods, the characteristics and contents of Alzheimer disease research documents were analyzed in Pubmed database and Wanfang web by analysis tools. Research status of Alzheimer disease including the type of literatures and journal distribution from 2008 to 2012 was analyzed. Currently hot topics or top high frequency words were emphatically analyzed. Results There were 646 matched literatures for Alzheimer disease retrieved in Chinese core periodicals, and 19 423 literatures in Pubmed database. The articles for clinical study of Alzheimer disease were more than experimental and epidemiologie study among the 646 literatures. The disciplines distribution of AD in Chinese core journals was similar to international journals, mainly including nerves, brain, and geriatrics journals. The domestic research papers on Alzheimer disease were less than 5 ~//0 in Pubmed database, and the articles from Chinese journals in Chinese or English edition accounted for only a small proportion of Pubmed database. The recent research direction of Alzheimer disease in China was similar to foreign countries such as amyloid proteins, diagnosis and gene, but foreign research paid more attention to the metabolism, image and the aging mechanism in AD, while in China there were quite a lot of reports in the literatures on cholinergic drugs, tau protein, hippocampus and Chinese herbal treatments. Conclusions The AD-related disciplines distribution in China and foreign country is relatively fixed in recent 5 years. The AD researches carried out in China are close to those in foreign country, but researches on some areas still lag behind. The experimental and epidemiologic study on AD should be strengthen in China.