摘要
本研究探讨TgAb阳性(>115IU/mL)、TgAb阴性(<115IU/mL)两组分化型甲状腺癌(DTC)患者血清甲状腺球蛋白(Tg)阳性率的差异;研究血清Tg测定值是否与TgAb浓度呈相关性。通过回顾性收集DTC甲状腺去除后的随访患者,计算TgAb阴性、TgAb阳性组的Tg阳性(>10μg/L)率,绘制TgAb-Tg散点图,从而分析TgAb浓度与Tg测定值的相关性。结果显示:收集到252例DTC随访患者中,有47例TgAb阳性的DTC患者,血清Tg阳性率为14.89%(7/47);剩余205例TgAb阴性的DTC患者,Tg阳性率为29.76%(61/205)。将有确切Tg、TgAb值的83例DTC患者分为TgAb阳性组、TgAb阴性组和混合组,3组的Tg测定值与TgAb浓度均没有相关性。结果表明TgAb阳性的DTC患者的Tg阳性率只有TgAb阴性DTC患者Tg阳性率的一半左右;血清Tg测定值与TgAb浓度没有相关性,不能用TgAb浓度预测对Tg测定值的干扰。
The first aim of this study was to compare the serum thyroglobulin（Tg） positive rate between differentiated thyroid carcinoma（DTC） patients with positive thyroglobulin antibody（TgAb） and patients with negative TgAb.The second aim of this study was to investigate the correlation between serum Tg value and antithyroglobulin（TgAb） concentration of patients with DTC.We collected the serum Tg value and TgAb concentration of patients with DTC after thyroid ablation by operation and radioiodine therapy retrospectively.Then we investigated the Tg positive rate of DTC patients with positive TgAb and patients with negative TgAb separately.The scatter diagram between serum Tg value and TgAb concentration of DTC patients was performed to analyze their potential relationship.As a result,among 252 patients with DTC after thyroid ablation,7 of 47 patients（14.89%） with positive TgAb（115 IU/mL） had positive serum Tg（10μg/L）,and 61 of 205（29.76%） patients with negative TgAb（115 IU/mL） had positive serum Tg.Eighty three of the 252 patients with DTC had accurate serum Tg and TgAb concentration.No correlation between serum Tg value and TgAb concentration was found among these Eighty three patients.Thus,it may be concluded that positive TgAb could cause much more TgAb interference in serum Tg value than negative TgAb could because of a different quality of TgAb.Serum Tg value is not correlated with serum TgAb concentration in patients with DTC after thyroid ablation.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2013年第4期803-807,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(30970859)
