凸隆病毒研究进展

Research Progress of Torovirus

凸隆病毒(torovirus)作为套式病毒目(Nidovirales)冠状病毒科(Coronaviridae)家族的重要成员,包括马凸隆病毒(EToV)、牛凸隆病毒(BToV)、猪凸隆病毒(PToV)和人凸隆病毒(HToV),该病毒感染人和动物,主要引起消化道和呼吸道疾病。自该病毒首次于1982年在美国Lowa州被分离得到,迄今已有30余年的研究历史,随着分子生物学和病毒分离培养技术的不断发展,病毒与其宿主间相互作用的机制也得以不断被认知,此篇综述介绍了有关凸隆病毒的最新研究进展,包括病毒的发现及分类,病毒粒子特征、基因结构及功能,引起细胞凋亡的机制,同时包含了病毒变异、血清流行病学、病理变化、诊断方法和关于研究前景的概括。

Torovirus, an important member of the Coronaviridae family in Nidovirales, contains four official species： equine torovirus, bovine torovirus, swine torovirus, and human torovirus, they are the agents cause gastroenteritis and respiratory diseases in different animal species and human. It has been 30 years since the virus firstly separated and reported in Lowa America, the progress in understanding the molecular epidemiology about torovirus and its hosts have been up- dating, this review introduced the most recently research progress of torovirus include finding and taxonomy, characteristic, genetic structure, mechanism of cell apoptosis, also contain variation, epidemiology, pathology, detection methods and a summary about possible research prospect.