内镜下套扎联合硬化术及药物治疗食管胃底静脉曲张出血的临床疗效观察

Endoscopic variceal sclerotherapy and clinical curative effect of combined drug treatment of esophageal varices bleeding observation

目的观察内镜下食管静脉曲张套扎联合硬化术及药物治疗肝硬化食管胃底静脉曲张出血(EGV)的临床疗效。方法回顾性分析86例确诊为肝硬化食管静脉曲张出血患者,随机分为对照组和观察组各43例,对照组行生长抑素、泮托拉唑、心得安等药物治疗,观察组行内镜下套扎联合聚桂醇硬化术及生长抑素、泮托拉唑、心得安等药物治疗,观察所有食管静脉曲张出血患者1、3、6、12、18个月后的临床效果。比较两组食管胃底静脉曲张总消失率、再出血率、不良反应及并发症发生率。结果观察组曲张静脉总消失率、早期再出血率、远期再出血率、不良反应及并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论内镜下食管静脉曲张套扎联合硬化术及药物治疗是治疗食管胃底静脉曲张出血安全有效的方法,疗效确切,提高了患者生存率,适合基层医院开展应用。

Objective To observe the clinical curative effect of endoscopic esophageal varices loop ligature joint sclerosis surgery and drug treatment of cirrhosis esophageal gastric varices bleeding （EGV）, Methods 86 cases diag- nosed as liver cirrhosis patients with esophageal varicea bleeding were randomly divided into control group and observation group. The control group （43 cases） was treated with somatostatin, panxi torn azole and propranolol. Observation group （43 cases） were treated with endoscopic loop ligature joint poly cinnamyl alcohol sclerosis, somatostatin, panxi tora azole and propranolol. The esophageal gastric varices total disappearance rate, rebleeding rate, adverse reaction and complica- tion rates were observed. Result The varicosis vein total rate, early rebleeding rate, forward bleeding rate, adverse re- action and complication rates of the obersavation group were significantly lower than that of the control group （P 〈0. 05）. Conclusion Sclerosis of endoscopic esophageal varices loop ligature joint surgery and drug therapy are is safe and effective for esophageal gastric varices bleeding.