1237例幽门螺杆菌流行病学调查研究

Epidemiological investigation into 1 237 cases of helicobacter pylori

目的通过了解近年来1237例幽门螺杆菌(helicobacter pylori,Hp)感染的情况,探讨与Hp感染相关的因素。方法研究对象为2010-11—2011-12本院健管中心体检人员共1237例,男1140例,女97例;年龄18～90岁。血浆中Hp尿素酶抗体检测方法采用北京康美天鸿生物科技有限公司所提供的胶体金试剂(其敏感度为98.91%;特异度为98.29%;总体符合率为98.51%,符合普查要求)。统计学处理组内和组间比较分别采用t检验和χ2检验,P<0.05为差异有统计学意义。结果 1237例Hp的总感染率为49%;不同性别的感染率显示男性为49%(556/1140),女性为48%(47/97),差异无统计学意义(P>0.05)。各年龄组血清Hp抗体感染率≤20岁为17%(1/6);21～30岁为29%(30/104);31～40岁为43%(118/276);41～50岁为49%(242/494);51～60岁为57%(138/243);≥61岁为65%(74/114);不同年龄组Hp感染率不同,年龄越大感染率越高(P<0.05)。结论 Hp感染率男性和女性无明显差异,随着年龄的增长阳性率呈上升趋势,及早发现Hp的感染和正确治疗对预防胃癌和预后有重要意义。

Objective To investigate the situation of helicobacter pylori(Hp)infection of 1 237 cases in recent years,and to explore the related factors with Hp infection.Methods 1 237 health examinees at our health care center from November,2010 to December, 2012 were taken as subjects with age ranging from 18 to 90 years old,among whom 1 140 were males and and 97 were females.Hp urease antibody in plasma was detected by means of the colloidal gold reagent offered by Beijing Kangmei Tianhong Biotechnology Company (sensitivity was 98.91% ,specificity was 98.29% and general coincidence rate was 98.51% ,which fit the general survey requirements).χ2 test and t test were used respectively to conduct statistical analysis within the group and between groups (P <0.05 was a statistically significant difference).Results The total infection rate of Hp among 1 237 cases was 49% ,infection rates between different genders showed 49% in males (556/1 140),48% in females(47/97),and the difference was not of statistical significance(P>0.05). Serum Hp antibodies infection rates for all age groups:the positive rate was 17% in ≤20 years group (1/6);the positive rate was 29% in 21 ～30 years group (30/104);the positive rate was 43% in 31 ～40 years group (118/276),the positive rates was 49% in 41 ～50 years group (242/494);the positive rate was 57% in 51 ～60 years group (138/243);the positive rate was 65% in ≥61 years group (74/114).Hp infection rates were different in different age groups;the older the age,the higher the infection rates (P <0.05).Conclusion Hp infection rates between men and women were not significantly different,the positive rates increase with age rising.Early detection of Hp infection and proper treatment were important for the prognosis and prevention of gastric cancer.