阿立哌唑与利培酮治疗精神分裂症的对照研究

Comparative Study on Aripiprazole and Risperidone in the Treatment of Schizophrenia

目的比较阿立哌唑和利培酮对精神分裂症的疗效,为临床用药提供参考。方法以我院2011年1月～2012年9月收治的120例精神分裂症患者为研究对象,将患者随机分为治疗组和对照组,每组60例。对照组患者应用利培酮,治疗组患者服用阿立哌唑。观察两组的治疗效果以及不良反应。结果治疗组总有效率高于对照组,但是差异不具有统计学意义(P>0.05);两组患者PANSS总分、阳性症状分、阴性症状分、一般精神病理分治疗后明显比治疗前降低(P<0.05),但是组间比较差异不具有统计学意义(P>0.05);治疗组不良反应发生率明显低于对照组(P<0.05)。结论临床对精神分裂症采用阿立哌唑和利培酮治疗效果均较显著,两种药物疗效相似;但是采用阿立哌唑治疗的不良反应发生率少,因此阿立哌唑治可作为临床的首要选择。

Objective Objective To analyze effect of aripiprazole and risperidone in the treatment of schizo- phrenia,and provide reference for clinical medication choice. Methods 120 cases with schizophrenia from in-patient department in January 2011 to September 2012 were selected. These patients were randomly di- vided into treatment group and control group, 60 cases in each group. Control group received risperidone, and treatment group received aripiprazole. Curative effect and adverse reaction for two groups were observed and compared. Results Total effective rate for treatment group was obviously higher than control group, but there were no significant difference （ P 〉 0.05 ）. PANSS score, positive symptoms score, negative symp- toms score and general psychopathology score after treatment were obviously lower than the score before treatment（ P 〈 0.05 ） , but there were no significant difference （ P 〉 0.05 ）. Incidence of adverse effect was obviously lower than control group （ P 〈 0.05 ）. Conclusion herapeutic effects of aripiprazole and risperi- done in the treatment of schizophrenia are remarkable and similar. Incidence of adverse reactions of aripi- prazole is less. It can be used as first choice of clinical medication. Therefore, it is worthy of application widely.