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血栓抽吸联合冠状动脉内注射替罗非班对急性心肌梗死预后影响 被引量:1

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摘要 选取2008年8月~2012年8月诊断为急性ST段抬高或非ST段抬高型心肌梗死并行急诊PCI治疗的患者110例,随机分为血栓抽吸联合冠状动脉内注射替罗非班组(冠状动脉内用药组)和血栓抽吸联合静脉滴注替罗非班组(静脉用药组)各55例。比较2组冠状动脉无复流发生率即刻靶血管TIMI血流分级[1]、矫正TIMI计帧数(CT-FC)[2]、用药后30d内出现事件、MACE发生率及术后30d心脏彩超左室射血分数(LVEF)/左室舒张末期内径(LVEDD)。结果与静脉用药组比较,冠状动脉内用药组无复流发生率明显减少(P=0.011);TIMI 3级比率升高(P=0.012);CTFC显示血流增快(P=0.008);左心室射血分数高(P=0.003);左室舒张末期内径改变基本持平;围术期大出血发生率增多(P=0.08),无统计学意义;30d随访期间的严重不良心脏事件明显降低(P=0.015)。血栓抽吸联合冠状动脉内注射替罗非班能有效改善心肌微循环的再灌注,降低围手术期的风险。
出处 《现代诊断与治疗》 CAS 2013年第8期1785-1786,共2页 Modern Diagnosis and Treatment
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参考文献6

  • 1Razakjr OA,Tan HC, Yip WL, et al. Predictors of bleedingcomplica- tions and thrombocytopenia withtheuseof abciximabduringpercutane- ous coronyintervention [ J]. J Interv Cardiol,2005,18( 1 ) :33-37.
  • 2Gibson CM, Cannon CP, Murphy SA, et al. Relationship of TIMI my- ocardial perfusion grade to mortality after administration of thrombo- lytic drugs [ J ]. Circulation, 2000,101 ( 02 ) : 125 - 130.
  • 3Zavala-Alarcon E, Cecena F, Little R, et al. The no-flow phenomenon during diagnostic coronary angiography[ J]. Cardiovasc Revasc Med, 2005,6 (3) : 126-132.
  • 4Yang TY, Chang ST, Chung CM, et al. Restoration of normal coronary flow with tiorifban by intracoronary administration for no relfow phe- nomenon after stent deployment [ J ]. Int Heart J, 2005,46 ( 1 ) : 139-145.
  • 5马东星,刘惠亮,姚宏英,穆雷,吴晓霞,韩玮,杨胜利,罗建平.急诊经皮冠状动脉介入治疗术中冠状动脉内注射盐酸替罗非班对急性ST段抬高型心肌梗死患者心肌灌注及心功能的影响[J].中国全科医学,2010,13(5):476-478. 被引量:48
  • 6Valgimigli M, Tebaldi M. Safety evaluation of tirofiban [ J ]. Expert Opin Drug Saf,2010,9(5) :801-819.

二级参考文献6

  • 1杨新春,徐立,王乐丰,葛永贵,王红石,丁枭伟,王文君,邹阳春,李惟铭,刘宇.国产替罗非班对急性心肌梗死患者急诊介入治疗术后冠状动脉血流和心肌灌注影响的研究[J].中国循环杂志,2006,21(1):4-7. 被引量:91
  • 2Uyarel H, Uzunlar B, Unal DS, et al. Effect of tirofiban therapy on ST segment resolution and clinical outcomes in patients with ST segment elevated acute myocardial infarction udergoing primary angioplasty [ J], Cardiology, 2006, 105 (3): 168-175.
  • 3Silber S, Albertsson P, Aviles FF, et al. Guidelines for percutaneous coronary interventions: the task force for percutaneous coronary interventions of the european society of cardiology [ J]. Eur Heart J, 2005, 26 (8) : 804 - 847.
  • 4Petronioa AS, Royal D, Musumeci G, et al. Effects of abeiximab on microvascular integrity and left ventricular functional recovery in patients with acute infarction tread by primary coronary angioplasty [ J ]. Ear Heart J, 2003, 24 (1): 67-76.
  • 5Yang TY, Chang ST, Chung CM, et al. Restoration of normal coronary flow with tirofiban by intracoronary administrion for no - reflow phenomenon after stent deployment [ J]. Int Heart J, 2005, 46 (1): 139 - 145.
  • 6卫丽,李学奇,金恩泽,王晓云.冠脉内注射替罗非班治疗急性冠脉综合征介入术后无复流的有效性和安全性[J].心脏杂志,2009,21(1):66-68. 被引量:10

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