神经上皮钙黏素蛋白转换对膀胱癌患者术后生存状况的预测价值

Predictive Value of Neuroepithelial Cadherin Protein Conversion on Postoperative Living Conditions of Patients with Bladder Cancer

目的探讨神经上皮(N-E)钙黏素蛋白转换对预测膀胱癌患者术后复发及预后的价值。方法选取膀胱癌患者50例作为临床研究对象。所有患者术前、术后均采用免疫组织化学SP法检测膀胱癌组织N-钙黏素蛋白、E-钙黏素蛋白的表达及N-E钙黏素蛋白转换情况。结果患者术后N-钙黏素蛋白表达阳性率为24.00%,较术前N-钙黏素蛋白表达阳性率明显降低;E-钙黏素蛋白的阴性表达率为64.00%,较术前E-钙黏素蛋白的阴性率明显升高;且N-E钙黏素蛋白转换率为26.00%,较术前N-E钙黏素蛋白转换率明显降低。N-钙黏素蛋白的表达阳性率、E-钙黏素蛋白阴性表达及N-E钙黏素蛋白转换与肿瘤低分化、高临床分期呈正相关。术后6个月、1年、3年后N-E钙黏素蛋白转换患者肿瘤复发率分别16.67%、33.33%、66.67%,均明显高于N-E钙黏素蛋白未转换患者,且术后1年、3年后生存率较N-E钙黏素蛋白未转换组低。N-E钙黏素蛋白转换患者术后肿瘤复发的平均间隔时间及肿瘤相关总生存期明显短于N-E钙黏素蛋白未转换患者,P<0.05,具有统计学意义。结论 N-E钙黏素蛋白转换是影响膀胱癌患者术后复发率、复发间隔时间及总生存期的重要因素,是预测膀胱癌术后生存状况的有效生化指标。

Objective To investigate the value of neuroepithelial（NE） cadherin protein conversion in predicting recurrence and prognosis of patients with bladder cancer.Methods 50 patients with bladder cancer was selected and studied.Expression of N-cadherin protein,E-cadherin protein and NE cadherin protein conversion of preoperative and postoperative bladder cancer patients were detected by immunohistochemical SP method.Results Postoperative positive rate of N-cadherin protein was 24.00%,it was significantly lower that that of preoperative patients;negative rate of E-cadherin protein was 64.00%,it was significantly higher than that of the preoperative patients;and NE-cadherin protein conversion rate was 26.00%,it was significantly lower after operation.N-cadherin protein positive rate,E-cadherin protein negative rate and NE cadherin protein conversion rate was positively correlated with tumor poorly differentiation and high clinical stage.Tumor recurrence of patients with NE cadherin protein conversion in 6-month,1-year,3-year was 16.67%,33.33%,66.67%,respectively.It was significantly higher than the NE cadherin protein unconverted patients,and 1-year,3-year postoperatively survival rate of NE cadherin protein unconverted group was higher.Mean interval between tumor recurrence and tumor-related overall survival of NE cadherin protein conversion patients was significantly shorter than the NE cadherin protein unconverted patients,（P0.05）,it was statistically significant.Conclusion NE cadherin protein conversion is an important influencing factor for recurrence rate,recurrence interval and overall survival of patients with bladder cancer,and it is an effective biochemical markers for predicting survival status of patients with bladder cancer.