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丝裂原活化蛋白激酶信号传导通路在恶性肿瘤中的研究现状 被引量：9

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摘要 丝裂原活化蛋白激酶（mitogen-activated protein kinases,MAPKs）是细胞内重要的信号传导通路之一,在细胞的增殖、分化、凋亡、血管生成、炎症和应激反应中发挥着重要作用。目前研究发现MAPKs通路主要包括以下4种类型：c-Jun氨基末端激酶（JNK）、p38激酶、细胞外信号调节蛋白激酶（ERK）和大丝裂原活化蛋白激酶（BMK1/ERK5）。
作者 鲁明骞 孔庆志
机构地区 湖北中医药大学 三峡大学肿瘤研究所 宜昌市中心人民医院 武汉市中心医院&武汉市肿瘤研究所
出处 《实用癌症杂志》 2013年第3期320-321,共2页 The Practical Journal of Cancer
基金 2012年宜昌市科技研究与开发项目(A12301-03)
关键词 丝裂原活化蛋白激酶 恶性肿瘤 信号传导通路
分类号 R730.23 [医药卫生—肿瘤]
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参考文献16

  • 1Dong X, Liu Y, Du M, et al. P38 mitogen-activated protein kinase in- hibition attenuates pulmonary inflammatory response in a rat cardiop- ulmonary bypass model [ J ]. Eur J Cardiothorac Surg, 2006,30 ( 1 ) :77.
  • 2Cheng Y J, Lee CH, Lin YP, et al. Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through the ERK pathway [ J]. Int J Cancer,2008,123 ( 6 ) : 1278.
  • 3Minden A, Lin A, Claret FX, et al. Selective activation of the JNK sig- naling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs [J]. Ce11,1995,81 (7) :1147.
  • 4Tournier C, Whitmarsh A J, Cavanagh J, et al. Mitogen-activated pro- tein kinase kinase 7 is an activator of the c-Jun NH2-terminal kina [J]. Proc Natl Acad Sci USA,1997,94(14) :7537.
  • 5Altiok N, Koyuturk M, Ahiok S. JNK pathway regulates estradiol-in- duced apoptosis in hormone-dependent human breast cancer cells [J]. Breast Cancer Res Treat,2007,105 (3) :247.
  • 6Brewster JL, de Valoir T, Dwyer ND, et al. An osmosensing signal transduction pathway in yeast [J]. Science, 1993,259 ( 5102 ) : 1760.
  • 7Raingeaud J, Whitmarsh AJ, Barrett T, et al. MKK3- and MKK6-regu- lated gene expression is mediated by the p38 mitogen-activated pro- tein kinase signal transduction pathway[J]. Mol Cell Biol, 1996,16 (3) :1247.
  • 8Jiang ~, Chen C, LI Z, et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta) [ J]. J Biol Chem, 1996,271 (30) : 17920.
  • 9Li Z, Jiang Y, Ulevitch ILl, et al. The primary structure of p38 gamma: a new member of p38 group of MAP kinases [J]. Biochem Biophys Res Commun,1996,228(2) :334.
  • 10Hsiao PW, Chang CC, Liu HF, et al. Activation of p38 mitogen-activa- ted protein kinase by celecoxib oppositely regulates survivin and gam- ma-H2AX in human eoloreetal cancer cells [ J ]. Toxieol Appl Phar- maco1,2007,222( 1 ) :97.

同被引文献117

  • 1闫泽强,杨玉珍.p27和p-ERK1/2在胃癌中的表达和意义[J].胃肠病学和肝病学杂志,2006,15(1):19-22. 被引量：3
  • 2黄佳,李锟,沈世强,罗和生.p27和p-ERK1/2在肝细胞癌中的表达及相关性研究[J].腹部外科,2007,20(2):118-119. 被引量：2
  • 3Lin A, Minden A, Martinetto H, et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2 [ J ]. Science, 1995,268 (5208) :286-290.
  • 4Hickson JA, Huo D, Vander Griend DJ, et al. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma[ J]. Cancer Res,2006,66(4) :2264-2270.
  • 5Whitmarsh A J, Davis RJ. Role of mitogen-activated protein kinase kinase 4 in cancer[J]. Oncogcne,2007,26(22) :3172-3184.
  • 6Teng DH, Perry lii WL, Hogan JK, et al. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor [ J ]. Cancer Res, 1997,57 (19) :4177-4182.
  • 7Cunningham SC, Kamangar F, Kim MP,et al. MKK4 status predicts survival after resection of gastric adenocarcinoma [ J ]. Arch Surg, 2006,141 ( 11 ) : 1095-1099.
  • 8Stark AM, Tongers K, Maass N, et al. Reduced metastasis- suppressor gene mRNA-expression in breast cancer brain metastases [ J ]. J Cancer Res Clin Oncol, 2005,131 ( 3 ) : 191-198.
  • 9Wang L, Pan Y, Dai JL. Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors [ J ]. Oncogene, 2004,23 ( 35 ) : 5978-5985.
  • 10Wu CW, Li AF, Chi CW, et al. Human gastric cancer kinase profile and prognostic significance otMKK4 kinase [ J ]. Am J Pathol, 2000,56 ( 6 ) : 2007 -2015.

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实用癌症杂志
2013年 第3期

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