家庭氧疗对COPD患者肺功能影响研究

Effect of home oxygen therapy on lung function in patients with chronic obstructive pulmonary disease at different stages

目的探讨不同临床分级慢性阻塞性肺疾病(COPD)患者经过长期家庭氧疗(LTOT)后肺功能变化情况。方法选取220例COPD患者按照肺功能分级不同分为四组,所有患者均进行长期家庭氧疗,四年后复测所有患者的肺功能及相关生化、动脉血气指标。结果四年后肺功能I、Ⅱ级患者的FEV1、FEV1/FVC%、FEV1%预计值及日间SaO2有下降趋势,且有统计学意义(P<0.05)。而在肺功能Ⅲ、Ⅳ级患者中上述指标然也有下降趋势,但这种趋势无统计学差异。结论长期家庭氧疗对于所有COPD患者均有益处,尤其对于肺功能Ⅲ、Ⅳ级患者其延缓肺功能恶化的作用更为显著。

Objective To explore the effect of long-term home oxygen therapy on lung function in COPD patients at different stages. Methods According to their different stages of pulmonary function, 220 patients with COPD were divided into four groups, and all of them were given the long-term family oxygen therapy. Their pulmonary function and related biochemical indexes were measured and compared among the four groups four years after the treatment. Results Four years after the treatment, the levels of FEV1, FEV1/ FVC% , FEV1% prediction value and SaO2 declined obviously in the COPD patients at stage Ⅰ and Ⅲ with statistical significance （P 〈 0. 05 ） , and they also declined in the COPD patients at stage Ⅲ and Ⅳ, but without statistical difference. Conclusion Long-term family oxygen therapy is effective for COPD patients, especially those patients at stage Ⅲ and Ⅳ.