COPD HRCT影像学表型与肺功能的相关性分析

Correlated analysis between HRCT imaging phenotypes and lung function of chronic obstructive lung disease

目的探讨慢性阻塞性肺病HRCT影像学表型与肺功能的相关性。方法分析了入住我院的120例COPD患者的临床资料,根据GOLD方案分级,其中Ⅰ级46例(A组)、Ⅱ级34例(B组)、Ⅲ级23例(C组)以及Ⅳ级17例(D组)。对本组全部入选患者的肺功能、血气分析以及HRCT等方面进行检查,对比上述四组之间的变化与相关性。结果与A组相比,B、C、D三组患者HRCT异常定量评分呈现出显著性升高的发展趋势,且比较差异具有统计学意义(P<0.05,P<0.01);而且,上述四组之间HRCT定量评价与肺功能分级具有较好的相关性(P<0.05)。结论 HRCT能够作为定量评价不同级别COPD患者的有效方法。

Objective To investigate the correlation between HRCT imaging phenotypes and lung function of chronic obstructive pulmonary disease. Methods The clinical data of 120 patients with COPD was retrospectively analyzed from June 2007 to June 2012 in our hospital. According to GOLD classification program, 120 patients were divided into the group A （grade I , 46 cases）, the group B （ grade II , 34 cases） , the group C （ grade ]II, 23 cases） , and the group D （ grade IV, 17 cases）. Lung function, blood gas analysis, and HRCT imaging phenotypes were compared among the 4 groups. Results Compared with the group A, the quantitative scores of HRCT abnormalities increased significantly in the rest 3 groups with statistical significance （P 〈0. 05, P 〈0. 01 ）. Moreover, the quanti- tative evaluation of HRCT showed a clear correlation with lung function classification （P 〈 0. 05 ）. Conclusion HRCT can be used as a quantitative evaluation of the different levels of COPD patients, which should be widely promoted in the clinical diagnosis and application.